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Researcher
Erik De Clercq
- Disciplines:Microbiology, Systems biology, Laboratory medicine
Affiliations
- Laboratory of Virology and Chemotherapy (Rega Institute) (Division)
Member
From1 Oct 1999 → 30 Sep 2013
Publications
21 - 30 of 564
- Linker optimization of HEPT derivatives as potent non-nucleoside HIV-1 reverse transcriptase inhibitors: From S =O to CHOR(2023)
Authors: Christophe Pannecouque, Erik De Clercq
- Structure-directed linker optimization of novel HEPTs as non-nucleoside inhibitors of HIV-1 reverse transcriptase(2023)
Authors: Christophe Pannecouque, Erik De Clercq
- Development of fluorine-substituted NH2- biphenyl-diarylpyrimidines as highly potent non-nucleoside reverse transcriptase inhibitors: Boosting the safety and metabolic stability(2023)
Authors: Christophe Pannecouque, Erik De Clercq
Pages: 1192 - 1203 - Comparative effectiveness of oseltamivir versus peramivir for hospitalized children (aged 0-5 years) with influenza infection(2023)
Authors: Erik De Clercq
Pages: 157 - 165 - From design to biological mechanism evaluation of phenylalanine-bearing HIV-1 capsid inhibitors targeting a vital assembly interface(2023)
Authors: Erik De Clercq, Christophe Pannecouque
- Poor glycemic control in type-2 diabetic patients infected with hepatitis B: A retrospective propensity-matched study(2023)
Authors: Erik De Clercq
- Structure-Based Optimization of 2,4,5-Trisubstituted Pyrimidines as Potent HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors: Exploiting the Tolerant Regions of the Non-Nucleoside Reverse Transcriptase Inhibitors' Binding Pocket(2023)
Authors: Erik De Clercq, Christophe Pannecouque
Pages: 2102 - 2115 - Identification of "dual-site"-binding diarylpyrimidines targeting both NNIBP and the NNRTI adjacent site of the HIV-1 reverse transcriptase(2023)
Authors: Erik De Clercq, Christophe Pannecouque
- Development of novel S-N3-DABO derivatives as potent non-nucleoside reverse transcriptase inhibitors with improved potency and selectivity(2023)
Authors: Christophe Pannecouque, Erik De Clercq
- Structure-guided design of novel HEPT analogs with enhanced potency and safety: From Isopropyl-HEPTs to Cyclopropyl-HEPTs(2023)
Authors: Christophe Pannecouque, Erik De Clercq
Patents
1 - 7 of 7
- Phosphonate nucleosides useful as active ingredients in pharmaceutical compositions for the treatment of viral infections, and intermediates for their production (Inventor)
- 6-[2-(PHOSPHONOMETHOXY)ALKOXY] PYRIMIDINE DERIVATIVES HAVING ANTIVIRAL ACTIVITY (Inventor)
- Phosphonate nucleosides useful as active ingredients in pharmaceutical compositions for the treatment of viral infections, and intermediates for their production (Inventor)
- Phosponate nucleosides useful as active ingredients in pharmaceutical compositions for the treatment of viral infections, and intermediates for their production (Inventor)
- VIRAL INHIBITORS (Inventor)
- VIRAL INHIBITORS (Inventor)
- PHOSPHONATE NUCLEOSIDES USEFUL AS ACTIVE INGREDIENTS IN PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF VIRAL INFECTIONS, AND INTERMEDIATES FOR THEIR PRODUCTION (Inventor)