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Researcher
Elisabetta Groaz
- Disciplines:Biomarker discovery and evaluation, Drug discovery and development, Medicinal products, Pharmaceutics, Pharmacognosy and phytochemistry, Pharmacology, Pharmacotherapy, Toxicology and toxinology, Other pharmaceutical sciences, Bioinformatics and computational biology
Affiliations
- Medicinal Chemistry (Rega Institute) (Division)
Member
From1 Apr 2007 → Today
Projects
1 - 10 of 10
- Development of modified anhydrohexitol nucleic acid (HNA) and altritol nucleic acid (ANA) antisense oligonucleotides to combat SARS-CoV-2From21 Nov 2022 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Dual targeting of nsp12 and nsp15: a powerful concept to suppress coronavirus replication and transcriptionFrom1 Oct 2022 → TodayFunding: IOF - technology concept exploration
- Stereo-controlled synthesis of artificial genetic systems with modified sugar phosphate backboneFrom10 Nov 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Structure-based design of HBV polymerase inhibitorsFrom13 Sep 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Synthesis of nucleoside analogues as antiviral and antibacterial agentsFrom10 Feb 2020 → 10 Feb 2024Funding: Own budget, for example: patrimony, inscription fees, gifts
- Synthesis and structure determination of phosphonate oligonucleotidesFrom17 Sep 2018 → 17 Sep 2022Funding: Own budget, for example: patrimony, inscription fees, gifts
- Xylo- and lyxo-type phosphonate nucleic acids: Synthesis and structural analysisFrom17 Sep 2018 → 17 Sep 2022Funding: Own budget, for example: patrimony, inscription fees, gifts
- Synthesis and biological evaluation of C-nucleoside analoguesFrom25 Sep 2015 → 23 Sep 2019Funding: Own budget, for example: patrimony, inscription fees, gifts
- SYNTHESIS OF NEW TYPES OF CHLORINE-CONTAINING NUCLEOSIDES AND 2',6-DISUBSTITUTED URIDINES FOR ANTIVIRAL/ANTICANCER SCREENINGFrom15 Jun 2014 → 7 Sep 2021Funding: Own budget, for example: patrimony, inscription fees, gifts
- Acyclic Phosphono Nucleosides, Nucleotides, and Oligonucleotides: Synthesis, Antiviral Evaluation, and Genetic SelectionFrom1 Sep 2013 → 31 Oct 2021Funding: SCK (Study Centre Nuclear Energy)
Publications
21 - 30 of 49
- Alternative pathways for vitamin biosynthesis mediated by in vitro selected nucleic acids(2020)
Authors: Nikolaos Papastavrou, Piet Herdewyn, Elisabetta Groaz
- Vitamin-guanosine monophosphate conjugates for in vitro transcription priming.(2020)
Authors: Nikolaos Papastavrou, Elisabetta Groaz, Piet Herdewyn
Pages: 2787 - 2790 - Synthesis of a Threosyl-C-nucleoside Phosphonate(2019)
Authors: Peng Nie, Elisabetta Groaz, Piet Herdewyn
Pages: 6666 - 6672 - Synthesis and biological evaluation of C-nucleoside analogues(2019)
Authors: Peng Nie, Piet Herdewyn, Steven De Jonghe, Elisabetta Groaz
- Synthesis of tetradialdose phosphonate nucleosides as mimics of L-nucleotides(2019)
Authors: Elisabetta Groaz, Piet Herdewyn
- Invading Escherichia coli Genetics with a Xenobiotic Nucleic Acid Carrying an Acyclic Phosphonate Backbone (ZNA)(2019)
Authors: Elisabetta Groaz, Mathy Froeyen, Piotr Leonczak, Jef Rozenski, Piet Herdewyn
Pages: 10844 - 10851 - Xylo-C-nucleosides with a pyrrolo [2,1-f] [1,2,4]triazin-4-amine heterocyclic base: Synthesis and antiproliferative properties(2019)
Authors: Peng Nie, Elisabetta Groaz, Dirk Daelemans, Piet Herdewyn
Pages: 1450 - 1453 - Synthesis and Conformation of Pentopyranoside Nucleoside Phosphonates(2019)
Authors: Shrinivas Dumbre, Eveline Lescrinier, Elisabetta Groaz, Piet Herdewyn
Pages: 6589 - 6603 - Highly stable hexitol based XNA aptamers targeting the vascular endothelial growth factor(2019)
Authors: Elena Eremeeva, Antonios Fikatas, Mikhail Abramov, Dominique Schols, Elisabetta Groaz, Piet Herdewyn
Pages: 4927 - 4939 - Synthesis and Anti-HIV Activity of Guanine Modified Fluorinated Acyclic Nucleoside Phosphonate Derivatives(2019)
Authors: Min Luo, Elisabetta Groaz, Steven De Jonghe, Dominique Schols, Piet Herdewyn
Patents
1 - 7 of 7
- Novel 6-substituted 7-deazapurines and corresponding nucleosides as medicaments (Inventor)
- Novel 6-substituted 7-deazapurines and corresponding nucleosides as medicaments (Inventor)
- Prodrugs of nucleoside phosphonates (Inventor)
- Novel prodrugs of nucleoside phosphonates (Inventor)
- Prodrugs of fluorinated acyclic nucleoside phosphonates (Inventor)
- Prodrugs of fluorinated acyclic nucleoside phosphonates (Inventor)
- Novel prodrugs of nucleoside phosphonates (Inventor)