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Researcher
Elisabetta Groaz
- Disciplines:Biomarker discovery and evaluation, Drug discovery and development, Medicinal products, Pharmaceutics, Pharmacognosy and phytochemistry, Pharmacology, Pharmacotherapy, Toxicology and toxinology, Other pharmaceutical sciences, Bioinformatics and computational biology
Affiliations
- Medicinal Chemistry (Rega Institute) (Division)
Member
From1 Apr 2007 → Today
Projects
1 - 10 of 10
- Development of modified anhydrohexitol nucleic acid (HNA) and altritol nucleic acid (ANA) antisense oligonucleotides to combat SARS-CoV-2From21 Nov 2022 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Dual targeting of nsp12 and nsp15: a powerful concept to suppress coronavirus replication and transcriptionFrom1 Oct 2022 → TodayFunding: IOF - technology concept exploration
- Stereo-controlled synthesis of artificial genetic systems with modified sugar phosphate backboneFrom10 Nov 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Structure-based design of HBV polymerase inhibitorsFrom13 Sep 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Synthesis of nucleoside analogues as antiviral and antibacterial agentsFrom10 Feb 2020 → 10 Feb 2024Funding: Own budget, for example: patrimony, inscription fees, gifts
- Synthesis and structure determination of phosphonate oligonucleotidesFrom17 Sep 2018 → 17 Sep 2022Funding: Own budget, for example: patrimony, inscription fees, gifts
- Xylo- and lyxo-type phosphonate nucleic acids: Synthesis and structural analysisFrom17 Sep 2018 → 17 Sep 2022Funding: Own budget, for example: patrimony, inscription fees, gifts
- Synthesis and biological evaluation of C-nucleoside analoguesFrom25 Sep 2015 → 23 Sep 2019Funding: Own budget, for example: patrimony, inscription fees, gifts
- SYNTHESIS OF NEW TYPES OF CHLORINE-CONTAINING NUCLEOSIDES AND 2',6-DISUBSTITUTED URIDINES FOR ANTIVIRAL/ANTICANCER SCREENINGFrom15 Jun 2014 → 7 Sep 2021Funding: Own budget, for example: patrimony, inscription fees, gifts
- Acyclic Phosphono Nucleosides, Nucleotides, and Oligonucleotides: Synthesis, Antiviral Evaluation, and Genetic SelectionFrom1 Sep 2013 → 31 Oct 2021Funding: SCK (Study Centre Nuclear Energy)
Publications
11 - 20 of 49
- Polymorphic and Higher-Order G-Quadruplexes as Possible Transcription Regulators: Novel Perspectives for Future Anticancer Therapeutic Applications(2022)
Authors: Elisabetta Groaz
- SYNTHESIS OF NEW TYPES OF CHLORINE-CONTAINING NUCLEOSIDES AND 2',6-DISUBSTITUTED URIDINES FOR ANTIVIRAL/ANTICANCER SCREENING(2021)
Authors: Fabio Da Paixao Soares, Piet Herdewyn, Elisabetta Groaz
- Introduction of a cyano group at the 2-position of an (R,S)-3-hydroxy-2-(phosphonomethoxy)propyl (HPMP) derivative of thymine elicits selective anti-HBV activity(2021)
Authors: Shuai Tan, Elisabetta Groaz, Piet Herdewyn
Pages: 804 - 808 - Influence of 4′-Substitution on the Activity of Gemcitabine and Its ProTide Against VZV and SARS-CoV-2(2021)
Authors: Zihua Zheng, Elisabetta Groaz, Robert Snoeck, Steven De Jonghe, Piet Herdewyn, Graciela Andrei
Pages: 88 - 92 - Overview of Biologically Active Nucleoside Phosphonates(2021)
Authors: Elisabetta Groaz, Steven De Jonghe
- Anno 2021: Which antivirals for the coming decade?(2021)
Authors: Elisabetta Groaz, Erik De Clercq, Piet Herdewyn
Pages: 49 - 107 - Scalable Synthesis, In Vitro cccDNA Reduction, and In Vivo Antihepatitis B Virus Activity of a Phosphonomethoxydeoxythreosyl Adenine Prodrug(2020)
Authors: Elisabetta Groaz, Steven De Jonghe, Piet Herdewyn
Pages: 13851 - 13860 - Synthesis and Antitumor Activity of C-7-Alkynylated and Arylated Pyrrolotriazine C-Ribonucleosides(2020)
Authors: Elisabetta Groaz, Dirk Daelemans, Piet Herdewyn
Pages: 1605 - 1610 - Amidate Prodrugs of O-2-Alkylated Pyrimidine Acyclic Nucleosides Display Potent Anti-Herpesvirus Activity(2020)
Authors: Elisabetta Groaz, Robert Snoeck, Graciela Andrei, Piet Herdewyn
Pages: 1410 - 1415 - Anti-norovirus activity of C7-modified 4-amino-pyrrolo[2,1-f][1,2,4]triazine C-nucleosides(2020)
Authors: Elisabetta Groaz, Joana Duarte Da Rocha Pereira, Johan Neyts, Piet Herdewyn
Patents
1 - 7 of 7
- Novel 6-substituted 7-deazapurines and corresponding nucleosides as medicaments (Inventor)
- Novel 6-substituted 7-deazapurines and corresponding nucleosides as medicaments (Inventor)
- Prodrugs of nucleoside phosphonates (Inventor)
- Novel prodrugs of nucleoside phosphonates (Inventor)
- Prodrugs of fluorinated acyclic nucleoside phosphonates (Inventor)
- Prodrugs of fluorinated acyclic nucleoside phosphonates (Inventor)
- Novel prodrugs of nucleoside phosphonates (Inventor)