Researcher
Elisabetta Groaz
- Disciplines:Biomarker discovery and evaluation, Drug discovery and development, Medicinal products, Pharmaceutics, Pharmacognosy and phytochemistry, Pharmacology, Pharmacotherapy, Toxicology and toxinology, Other pharmaceutical sciences, Bioinformatics and computational biology
Affiliations
- Medicinal Chemistry (Rega Institute) (Division)
Member
From1 Apr 2007 → Today
Projects
1 - 10 of 10
- Development of modified anhydrohexitol nucleic acid (HNA) and altritol nucleic acid (ANA) antisense oligonucleotides to combat SARS-CoV-2From21 Nov 2022 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Dual targeting of nsp12 and nsp15: a powerful concept to suppress coronavirus replication and transcriptionFrom1 Oct 2022 → TodayFunding: IOF - technology concept exploration
- Stereo-controlled synthesis of artificial genetic systems with modified sugar phosphate backboneFrom10 Nov 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Structure-based design of HBV polymerase inhibitorsFrom13 Sep 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Synthesis of nucleoside analogues as antiviral and antibacterial agentsFrom10 Feb 2020 → 10 Feb 2024Funding: Own budget, for example: patrimony, inscription fees, gifts
- Synthesis and structure determination of phosphonate oligonucleotidesFrom17 Sep 2018 → 17 Sep 2022Funding: Own budget, for example: patrimony, inscription fees, gifts
- Xylo- and lyxo-type phosphonate nucleic acids: Synthesis and structural analysisFrom17 Sep 2018 → 17 Sep 2022Funding: Own budget, for example: patrimony, inscription fees, gifts
- Synthesis and biological evaluation of C-nucleoside analoguesFrom25 Sep 2015 → 23 Sep 2019Funding: Own budget, for example: patrimony, inscription fees, gifts
- SYNTHESIS OF NEW TYPES OF CHLORINE-CONTAINING NUCLEOSIDES AND 2',6-DISUBSTITUTED URIDINES FOR ANTIVIRAL/ANTICANCER SCREENINGFrom15 Jun 2014 → 7 Sep 2021Funding: Own budget, for example: patrimony, inscription fees, gifts
- Acyclic Phosphono Nucleosides, Nucleotides, and Oligonucleotides: Synthesis, Antiviral Evaluation, and Genetic SelectionFrom1 Sep 2013 → 31 Oct 2021Funding: SCK (Study Centre Nuclear Energy)
Publications
31 - 40 of 49
- Synthesis of a 3′-Deoxy-C-Nucleoside Phosphonate Bearing 9-Deazaadenine as Base Moiety(2018)
Authors: Peng Nie, Elisabetta Groaz, Steven De Jonghe, Graciela Andrei, Piet Herdewyn
Pages: 6657 - 6664 - Phosphorus Pentachloride Promoted gem-Dichlorination of 2'- and 3'-Deoxynucleosides.(2018)
Authors: Fabio Da Paixao Soares, Elisabetta Groaz, Piet Herdewyn
- Phosphonomethyl Oligonucleotides as Backbone-Modified Artificial Genetic Polymers(2018)
Authors: Jef Rozenski, Shrinivas Dumbre, Vitor Bernardes Pinheiro, Elisabetta Groaz, Piet Herdewyn
Pages: 6690 - 6699 - Amidate prodrugs of cyclic 9-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]adenine with potent anti-herpesvirus activity(2018)
Authors: Min Luo, Elisabetta Groaz, Steven De Jonghe, Robert Snoeck, Graciela Andrei, Piet Herdewyn
Pages: 381 - 385 - Synthesis of a C-Nucleoside Phosphonate by Base-Promoted Epimerization(2018)
Authors: Peng Nie, Elisabetta Groaz, Steven De Jonghe, Eveline Lescrinier, Piet Herdewyn
Pages: 1203 - 1206 - Synthesis and biological evaluation of pyrrolo[2,1-f][1,2,4]triazine C-nucleosides with a ribose, 2-deoxyribose, and 2,3-dideoxyribose sugar moiety(2018)
Authors: Li Qingfeng, Eveline Lescrinier, Elisabetta Groaz, Dirk Daelemans, Piet Herdewyn, Steven De Jonghe
Pages: 97 - 104 - Acyclic Phosphono Nucleosides, Nucleotides, and Oligonucleotides: Synthesis, Antiviral Evaluation, and Genetic Selection(2017)
Authors: Min Luo, Piet Herdewyn, Elisabetta Groaz
- Expanding the antiviral spectrum of 3-fluoro-2-(phosphonomethoxy)propyl acyclic nucleoside phosphonates: diamyl aspartate amidate prodrugs(2017)
Authors: Min Luo, Elisabetta Groaz, Graciela Andrei, Robert Snoeck, Dominique Schols, Steven De Jonghe, Piet Herdewyn
Pages: 6220 - 6238 - Syntheses of 5'-Nucleoside Monophosphate Derivatives with Unique Aminal, Hemiaminal, and Hemithioaminal Functionalities: A New Class of 5'-Peptidyl Nucleotides(2016)
Authors: Swarup De, Elisabetta Groaz, Piet Herdewyn
Pages: 8167 - 8180 - Nucleosides with Transposed Base or 4'-Hydroxymethyl Moieties and Their Corresponding Oligonucleotides(2015)
Authors: Marleen Renders, Elisabetta Groaz, Piet Herdewyn
Pages: 13484 - 525
Patents
1 - 7 of 7
- Novel 6-substituted 7-deazapurines and corresponding nucleosides as medicaments (Inventor)
- Novel 6-substituted 7-deazapurines and corresponding nucleosides as medicaments (Inventor)
- Prodrugs of nucleoside phosphonates (Inventor)
- Novel prodrugs of nucleoside phosphonates (Inventor)
- Prodrugs of fluorinated acyclic nucleoside phosphonates (Inventor)
- Prodrugs of fluorinated acyclic nucleoside phosphonates (Inventor)
- Novel prodrugs of nucleoside phosphonates (Inventor)