Researcher
Diether Lambrechts
- Disciplines (Flanders Institute for Biotechnology):Analysis of next-generation sequence data, Cell death, Cancer biology
- Disciplines (KU Leuven):Morphological sciences, Oncology
Affiliations
- Laboratory of Translational Genetics (VIB-KU Leuven) (Division)
Responsible
From1 Jan 2017 → Today - VIB-KU Leuven Center for Cancer Biology (Research Center)
Responsible
From1 Jan 2017 → Today - Lambrechts Lab (Research group)
Responsible
From1 Jan 2017 → Today - Laboratory of Translational Genetics (VIB-KU Leuven) (Division)
Member
From1 Jan 2012 → Today - Centre for Molecular and Vascular Biology (Division)
Member
From1 Oct 2003 → 30 Sep 2005 - Department of Cellular and Molecular Medicine (Department)
Member
From1 Oct 1999 → 30 Sep 2003
Projects
1 - 10 of 72
- Liquid biopsy and HRD testing in ovarian cancerFrom4 Oct 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Decoding the penile cancer tumor microenvironment: heterogeneity of tumor-associated epithelial cell states, it's relationship with HPV, and it's role in prognosis and therapy response.From1 Oct 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Integration of Spatial Transcript- and Proteomics Techniques with Pan-cancer single cell RNA-sequencing data to interrogate the impact of immunotherapy on the Tumor Microenvironment (TME)From9 May 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- An Integrated Spatial Atlas of the Tumor Micro-environment of Early Non-Small Cell Lung CancerFrom16 Mar 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Abemaciclib and letrozole in ER positive rare ovarian cancerFrom1 Mar 2023 → TodayFunding: Foundations, funds and other with scientific goal
- SymBioSys: Computationally mapping genomic heterogeneity from long read sequencing dataFrom1 Oct 2022 → TodayFunding: BOF - projects
- Refining the role of dual checkpoint inhibition in advanced lung cancer: a single-cell approachFrom5 Oct 2021 → TodayFunding: FWO Strategic Basic Research Grant
- Multiomic Integration of cell-free DNA profiles to Advance Disease OutcomeFrom1 Oct 2021 → TodayFunding: FWO Strategic Basic Research (SBO)
- Connecting Single-cell Immune Profiling in Peripheral Blood with Intratumoral T Cell Expansion in Breast Cancer Upon Checkpoint ImmunotherapyFrom24 Aug 2021 → TodayFunding: FWO Strategic Basic Research Grant
- Developing personalized treatment for advanced penile cancer trough establishment of Patient-Derived Tumor Xenografts (PDTXs).From9 Aug 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
Publications
31 - 40 of 610
- Intermediate Molecular Phenotypes to Identify Genetic Markers of Anthracycline-Induced Cardiotoxicity Risk(2023)
Authors: Sigrid Hatse, Diether Lambrechts, Hans Wildiers
- Obesity-associated changes in molecular biology of primary breast cancer(2023)
Authors: Ha Linh Nguyen, Tatjana Geukens, Maxim De Schepper, Stefan Naulaerts, Ines Nevelsteen, Patrick Neven, Karen Van Baelen, Hanne Vos, Hans Wildiers, Beppe Floris, et al.
- Transcriptional and spatial profiling of the kidney allograft unravels a central role for FcyRIII plus innate immune cells in rejection(2023)
Authors: Yannick Van Herck, Frederik De Smet, Katrien De Vusser, Amelie Franken, Dirk Kuypers, Diether Lambrechts, Elisabet Van Loon, Thibaut Vaulet, Francesca Bosisio, Maarten Naesens
- PARP inhibitor predictive value of the Leuven HRD test compared with Myriad MyChoice CDx PLUS HRD on 468 ovarian cancer patients from the PAOLA-1/ENGOT-ov25 trial(2023)
Authors: Liselore Loverix, Ignace Vergote, Pieter Busschaert, Tom Venken, Bram Boeckx, Hilde Brems, Els Van Nieuwenhuysen, Thaïs Baert, Sileny Han, Patrick Neven, et al.
Pages: 131 - 139 - C5aR1 signaling triggers lung immunopathology in COVID-19 through neutrophil extracellular traps(2023)
Authors: Seppe Cambier, Fabio Beretta, Pierre Van Mol, Simon Feys, Els Wauters, Diether Lambrechts, Paul Proost
- Neoadjuvant durvalumab and tremelimumab in resectable locally advanced SCC of the oral cavity: DUTRELASCO study(2023)
Authors: Paul Clement, Diether Lambrechts, Vincent Vander Poorten, Sigrid Hatse, Jeroen Van Dessel, Esther Hauben, Karolien Goffin
- Comparative analysis of deeply phenotyped GBM cohorts of 'short-term' and 'long-term' survivors(2023)
Authors: Ingrid Arijs, Diether Lambrechts
Pages: 327 - 338 - Transcription factor NKX2-1 drives serine and glycine synthesis addiction in cancer(2023)
Authors: Elien Heylen, Paulien Verstraete, Linde Van Aerschot, Tom Venken, David Nittner, Anne Uyttebroeck, Heidi Segers, Diether Lambrechts, Jan Cools, Kim De Keersmaecker, et al.
Pages: 1862 - 1878 - Organoids from mouse molar and incisor as new tools to study tooth-specific biology and development(2023)
Authors: Florian Hermans, Celine Bueds, Diether Lambrechts, Hugo Vankelecom
Pages: 1166 - 1181 - A NOVEL GENE ENHANCER ENRICHED DNA METHYLATION SIGNATURE DEMONSTRATES DIAGNOSTIC AND THERAPEUTIC POTENTIAL TO PREDICT AND IMPEDE COLORECTAL CANCER PROGRESSION(2023)
Authors: Diether Lambrechts, Bernard Thienpont
Pages: S25 - S25
Patents
1 - 10 of 10
- Predicting chronic allograft injury through age-related dna methylation (Inventor)
- Disease detection in liquid biopsies (Inventor)
- Retrotransposon biomarkers (Inventor)
- Detection of ovarian cancer in liquid biopsies (Inventor)
- Markers for determining tumor hypoxia (Inventor)
- Disease detection in liquid biopsies (Inventor)
- Predicting chronic allograft injury through age-related dna methylation (Inventor)
- Predicting age using dna methylation signatures (Inventor)
- Retrotransposon biomarkers (Inventor)
- Predicting chronic allograft injury through ischemia-induced dna methylation (Inventor)