Researcher
Diether Lambrechts
- Disciplines (Flanders Institute for Biotechnology):Analysis of next-generation sequence data, Cell death, Cancer biology
- Disciplines (KU Leuven):Morphological sciences, Oncology
Affiliations
- Laboratory of Translational Genetics (VIB-KU Leuven) (Division)
Responsible
From1 Jan 2017 → Today - VIB-KU Leuven Center for Cancer Biology (Research Center)
Responsible
From1 Jan 2017 → Today - Lambrechts Lab (Research group)
Responsible
From1 Jan 2017 → Today - Laboratory of Translational Genetics (VIB-KU Leuven) (Division)
Member
From1 Jan 2012 → Today - Centre for Molecular and Vascular Biology (Division)
Member
From1 Oct 2003 → 30 Sep 2005 - Department of Cellular and Molecular Medicine (Department)
Member
From1 Oct 1999 → 30 Sep 2003
Projects
41 - 50 of 72
- CRYPTIC TRANSCRIPTS: THE MASKED HEROES WHO BREAK TUMOR IMMUNE TOLERANCE AND FREE THE RESPONSE TO IMMUNE THERAPY.From1 Oct 2015 → 31 Jul 2021Funding: FWO fellowships
- Postpartum breast cancer diagnosed during the post-weaning period: a distinct entity with unique clinicopathological, molecular and immunological features?From22 Sep 2015 → 9 Jan 2023Funding: Private funding of national origin - undefined
- Combining metabolomics and genomics technologies to study platinum-based therapeutic failure in high grade ovarian cancers: from predictive signature(s) to novel therapeutic strategies.From1 Sep 2015 → 31 Aug 2019Funding: Private funding of national origin - undefined
- Assessment of differences in the anti-tumor immune response between lung cancer patients with and without COPD.From1 Jan 2015 → 31 Dec 2018Funding: FWO research project (including WEAVE projects)
- Hypoxia-mediated DNA demethylation events underlying adaptive resistance to anti-angiogenic therapies.From1 Jan 2015 → 31 Dec 2018Funding: FWO research project (including WEAVE projects)
- Platform for integrating psychological, pneumological, genetic, rehabilitative, immunological and neural aspects of dyspneaFrom10 Sep 2014 → 9 Mar 2019Funding: Hercules - Small and Medium size research infrastructure
- Metabolism enhances tumorigenesis by alterations that mitigate 5mC oxidation and result in the formation of epimutationsFrom1 Jan 2014 → 31 Dec 2014Funding: FWO research grant KAN
- The effect of changes in the innate and adaptive immune compartment within the renal allograft on graft outcomeFrom1 Oct 2013 → 30 Sep 2018Funding: FWO fellowships
- Mutation profiles and targeted treatment options for mismatch repair deficient tumors.From1 Jan 2013 → 31 Dec 2014Funding: Private funding of national origin - undefined
- Preclinical evaluation of targeted therapies in endometrial cancer: use of primary in vitro and in vivo models.From1 Jan 2013 → 31 Dec 2016Funding: FWO research project (including WEAVE projects)
Publications
1 - 10 of 610
- Single-Cell Omics to Reveal Mechanisms of Response to Immunotherapy in Head and Neck Cancer(2024)
Authors: Amelie Franken, Diether Lambrechts, Paul Clement
- Clinical and genetic determinants of vitamin D receptor expression in cutaneous melanoma patients.(2024)
Authors: Laudine Janssen, Veerle Boecxstaens, Isabelle Cleynen, Dirk Vanderschueren, Katleen Vandenberghe, Oliver Bechter, Diether Lambrechts, Maria Garmyn
Pages: 125 - 133 - A phase II, multicenter, open-label study of abemaciclib and letrozole in patients with estrogen receptor-positive rare ovarian cancer: ALEPRO trial(2024)
Authors: Tine Ottenbourgs, Toon Van Gorp, Thaïs Baert, Anne-Sophie Van Rompuy, Diether Lambrechts, Els Van Nieuwenhuysen
- CD4+ T cell activation distinguishes response to anti-PD-L1+anti-CTLA4 therapy from anti-PD-L1 monotherapy.(2024)
Authors: Amelie Franken, Michel Bila, Aurelie Mechels, Jeroen Van Dessel, Bram Boeckx, Sigrid Hatse, Esther Hauben, Vincent Vander Poorten, Katy Vandereyken, Sabine Tejpar, et al.
Pages: 541 - 558.e7 - Genome-wide association analyses of ovarian cancer patients undergoing primary debulking surgery identify candidate genes for residual disease.(2024)
Authors: Diether Lambrechts
Pages: 19 - Tumoral and stromal hMENA isoforms impact tertiary lymphoid structure localization in lung cancer and predict immune checkpoint blockade response in patients with cancer.(2024)
Authors: Diether Lambrechts, Jieyi Xiong
Pages: 105003 - Lower respiratory tract single-cell RNA sequencing and neutrophil extracellular trap profiling of COVID-19-associated pulmonary aspergillosis: a single centre, retrospective, observational study.(2024)
Authors: Simon Feys, Sam Vanmassenhove, Bram Boeckx, Seppe Cambier, Yves Debaveye, Greet Hermans, Katrien Lagrou, Johan Neyts, Marijke Peetermans, Joana Duarte Da Rocha Pereira, et al.
Pages: e247 - e260 - Comparison of the single-cell and single-nucleus hepatic myeloid landscape within decompensated cirrhosis patients(2024)
Authors: Lukas Van Melkebeke, Jef Verbeek, Bram Boeckx, Lena Smets, Olivier Govaere, Diether Lambrechts, Schalk Van der Merwe
- A TCF4-dependent gene regulatory network confers resistance to immunotherapy in melanoma(2024)
Authors: Dennis Pedri, Ewout Landeloos, Yannick Van Herck, Katy Vandereyken, Thierry Voet, Wim Annaert, Diether Lambrechts, Veerle Boecxstaens, Joost van den Oord, Francesca Bosisio, et al.
- Heterozygous mutations in the C-terminal domain of COPA underlie a complex autoinflammatory syndrome.(2024)
Authors: Selket Delafontaine, Daisy Rymen, Katrien Jansen, Djalila Mekahli, Rik Schrijvers, Xavier Bossuyt, Bram Boeckx, Lisa Ehlers, Sebastian Munck, Diether Lambrechts, et al.
Pages: e163604
Patents
1 - 10 of 10
- Predicting chronic allograft injury through age-related dna methylation (Inventor)
- Disease detection in liquid biopsies (Inventor)
- Retrotransposon biomarkers (Inventor)
- Detection of ovarian cancer in liquid biopsies (Inventor)
- Markers for determining tumor hypoxia (Inventor)
- Disease detection in liquid biopsies (Inventor)
- Predicting chronic allograft injury through age-related dna methylation (Inventor)
- Predicting age using dna methylation signatures (Inventor)
- Retrotransposon biomarkers (Inventor)
- Predicting chronic allograft injury through ischemia-induced dna methylation (Inventor)