Researcher
Diether Lambrechts
- Disciplines (Flanders Institute for Biotechnology):Analysis of next-generation sequence data, Cell death, Cancer biology
- Disciplines (KU Leuven):Morphological sciences, Oncology
Affiliations
- Laboratory of Translational Genetics (VIB-KU Leuven) (Division)
Responsible
From1 Jan 2017 → Today - VIB-KU Leuven Center for Cancer Biology (Research Center)
Responsible
From1 Jan 2017 → Today - Lambrechts Lab (Research group)
Responsible
From1 Jan 2017 → Today - Laboratory of Translational Genetics (VIB-KU Leuven) (Division)
Member
From1 Jan 2012 → Today - Centre for Molecular and Vascular Biology (Division)
Member
From1 Oct 2003 → 30 Sep 2005 - Department of Cellular and Molecular Medicine (Department)
Member
From1 Oct 1999 → 30 Sep 2003
Projects
11 - 20 of 71
- Alternative RNA splicing as a predictor of response to checkpoint immunotherapyFrom1 Mar 2021 → TodayFunding: Foundations, funds and other with scientific goal
- Exploring the reciprocal crosstalk between the vasculature in cancer to improve immunotherapyFrom15 Feb 2021 → TodayFunding: FWO fellowships, Foundations, funds and other with scientific goal
- Single-cell omics data analysis in translational oncologyFrom1 Feb 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Epigenetic and Spatial Single-cell profiling in the context of Cancer ImmunotherapyFrom1 Jan 2021 → TodayFunding: FWO research project (including WEAVE projects)
- EU-Genomics: EU Infrastructure for Genome AnalysisFrom1 Jan 2021 → TodayFunding: FWO Large scale research infrastructure
- Exploring the heterogeneity of rare ovarian cancerDefining (epi)genomic transition from precursor lesion to invasive rare ovarian cancerFrom1 Apr 2020 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- T Cell Expansion and Tumour Neoantigen Evolution during Checkpoint ImmunotherapyFrom1 Jan 2020 → 31 Dec 2023Funding: FWO research project (including WEAVE projects)
- Development of an interdisciplinary platform for spatial multi-omic analysis of single cellsFrom1 Oct 2019 → 30 Sep 2023Funding: BOF - projects
- The search for biomarkers in systemic treatment of advanced hepatocellular carcinoma.From1 Oct 2019 → 1 Oct 2023Funding: FWO Strategic Basic Research Grant
- Single-Cell Omics to Reveal Mechanisms of Response to Immunotherapy in Head and Neck CancerSingle-Cell Omics to Reveal Mechanisms of Response to Immunotherapy in Head and Neck CancerSingle-Cell Omics to Reveal Mechanisms of Response to Immunotherapy in Head and Neck CancerFrom1 Sep 2019 → 1 Sep 2023Funding: Foundations, funds and other with scientific goal
Publications
1 - 10 of 608
- Clinical and genetic determinants of vitamin D receptor expression in cutaneous melanoma patients.(2024)
Authors: Laudine Janssen, Veerle Boecxstaens, Isabelle Cleynen, Dirk Vanderschueren, Katleen Vandenberghe, Oliver Bechter, Diether Lambrechts, Maria Garmyn
Pages: 125 - 133 - CD4+ T cell activation distinguishes response to anti-PD-L1+anti-CTLA4 therapy from anti-PD-L1 monotherapy.(2024)
Authors: Aurelie Mechels, Jeroen Van Dessel, Bram Boeckx, Sigrid Hatse, Esther Hauben, Vincent Vander Poorten, Katy Vandereyken, Paul Clement, Diether Lambrechts
Pages: 541 - 558.e7 - Genome-wide association analyses of ovarian cancer patients undergoing primary debulking surgery identify candidate genes for residual disease.(2024)
Authors: Diether Lambrechts
Pages: 19 - Tumoral and stromal hMENA isoforms impact tertiary lymphoid structure localization in lung cancer and predict immune checkpoint blockade response in patients with cancer.(2024)
Authors: Diether Lambrechts, Jieyi Xiong
Pages: 105003 - Lower respiratory tract single-cell RNA sequencing and neutrophil extracellular trap profiling of COVID-19-associated pulmonary aspergillosis: a single centre, retrospective, observational study.(2024)
Authors: Simon Feys, Sam Vanmassenhove, Bram Boeckx, Seppe Cambier, Yves Debaveye, Greet Hermans, Katrien Lagrou, Johan Neyts, Marijke Peetermans, Joana Duarte Da Rocha Pereira, et al.
Pages: e247 - e260 - Comparison of the single-cell and single-nucleus hepatic myeloid landscape within decompensated cirrhosis patients(2024)
Authors: Lukas Van Melkebeke, Jef Verbeek, Bram Boeckx, Lena Smets, Olivier Govaere, Diether Lambrechts, Schalk Van der Merwe
- Heterozygous mutations in the C-terminal domain of COPA underlie a complex autoinflammatory syndrome.(2024)
Authors: Selket Delafontaine, Daisy Rymen, Katrien Jansen, Djalila Mekahli, Rik Schrijvers, Xavier Bossuyt, Bram Boeckx, Lisa Ehlers, Sebastian Munck, Diether Lambrechts, et al.
Pages: e163604 - A TCF4-dependent gene regulatory network confers resistance to immunotherapy in melanoma(2024)
Authors: Dennis Pedri, Ewout Landeloos, Yannick Van Herck, Katy Vandereyken, Thierry Voet, Wim Annaert, Diether Lambrechts, Veerle Boecxstaens, Joost van den Oord, Francesca Bosisio, et al.
- Integrated analysis of transcriptomic and proteomic alterations in mouse models of ALS/FTD identify early metabolic adaptions with similarities to mitochondrial dysfunction disorders(2024)
Authors: Ingrid Arijs, Diether Lambrechts
Pages: 135 - 149 - Immune checkpoint biology in health & disease: Immune checkpoint biology and autoimmunity in cancer patients.(2024)
Authors: Diether Lambrechts, Els Wauters
Pages: 181 - 206
Patents
1 - 10 of 10
- Predicting chronic allograft injury through age-related dna methylation (Inventor)
- Disease detection in liquid biopsies (Inventor)
- Retrotransposon biomarkers (Inventor)
- Detection of ovarian cancer in liquid biopsies (Inventor)
- Markers for determining tumor hypoxia (Inventor)
- Disease detection in liquid biopsies (Inventor)
- Predicting chronic allograft injury through age-related dna methylation (Inventor)
- Predicting age using dna methylation signatures (Inventor)
- Retrotransposon biomarkers (Inventor)
- Predicting chronic allograft injury through ischemia-induced dna methylation (Inventor)