Researcher
Bart Vandekerckhove
- Keywords:Advanced therapy medicinal products, GMP, immunotherapy
- Disciplines:Other medical and health sciences not elsewhere classified, Adaptive immunology, Medicinal products not elsewhere classified, Cancer therapy
Affiliations
- Department of Diagnostic Sciences (Department)
Member
From1 Oct 2018 → Today - Department of Clinical chemistry, microbiology and immunology (Department)
Member
From1 Jan 1993 → 30 Sep 2018
Projects
11 - 20 of 30
- Regucyte : Bringing Regenerative Medicine to the ClinicFrom15 Apr 2021 → TodayFunding: IOF - technology validation in lab
- Improving Neo-epitope Identification in lung cancer patients using Mass spectrometry and next generation sequencing (INI-M&N)From1 Mar 2021 → TodayFunding: Foundations, funds and other with scientific goal
- Proteomics-derived epitopes for dramatically improved anticancer and antibacterial vaccine developmentFrom1 Jan 2021 → TodayFunding: BOF - projects
- Light-triggered self-assembled nanostructures for efficient and safe production of engineered therapeutic immune cellsFrom1 Nov 2020 → TodayFunding: FWO Strategic Basic Research Grant
- Study of inducible glycome manipulation of CAR-T cells upon antigen exposure in the tumor environmentFrom1 Nov 2020 → 31 Dec 2023Funding: FWO fellowships
- Combining photoporation with electrophoresis for improved transfection of hard-to-transfect cellsFrom1 Oct 2020 → TodayFunding: BOF - projects
- In-depth comparison and feasibility assessment of an integrated pipeline for neoantigen identification and HLA ligandome sequencing in a clinical settingFrom1 Nov 2019 → 31 Oct 2023Funding: FWO Strategic Basic Research Grant
- Vaccination with nucleoside-modified mRNA-ceramide lipoplexes: a phase I trial in stage IV lung carcinoma patientsFrom1 Oct 2019 → TodayFunding: Nonprofit institution or equivalents
- Immunomonitoring of patients with non-small cell lung carcinoma treated with a tumor mutanome-targeted dendritic cell vaccineFrom1 Jan 2018 → 31 Dec 2021Funding: BOF - Doctoral projects
- Generation of "off the shelf" nano-chimeric antigen receptor tranduced cell linesFrom1 Jul 2017 → 30 Jun 2019Funding: Nonprofit institution or equivalents
Publications
1 - 10 of 34
- Gene editing-based targeted integration for correction of Wiskott-Aldrich syndrome(2024)
Authors: Melissa Pille, John M. Avila, So Hyun Park, Cuong Q. Le, Haipeng Xue, Filomeen Haerynck, Lavanya Saxena, Ciaran Lee, Elizabeth J. Shpall, Gang Bao, et al.
- Single-cell profiling identifies a novel human polyclonal unconventional T cell lineage(2023)
Authors: Lore Billiet, Laurenz De Cock, Guillem Sanchez Sanchez, Rupert Mayer, Glenn Goetgeluk, Stijn De Munter, Melissa Pille, Joline Ingels, Hanne Jansen, Karin Weening, et al.
- Intrathymic dendritic cell-biased precursors promote human T cell lineage specification through IRF8-driven transmembrane TNF(2023)
Authors: Kai Ling Liang, Juliette Roels, Marieke Lavaert, Tom Putteman, Lena Böhme, Laurentijn Tilleman, Imke Velghe, Valentina Pegoretti, Inge Van de Walle, Stephanie Sontag, et al.
Pages: 474 - 486 - Transcriptional dynamics and epigenetic regulation of E and ID protein encoding genes during human T cell development(2022)
Authors: Juliette Roels, Jolien Van Hulle, Marieke Lavaert, Anna Kuchmiy, Steven Strubbe, Tom Putteman, Bart Vandekerckhove, Georges Leclercq, Filip Van Nieuwerburgh, Lena Böhme, et al.
- In vitro OP9-DL1 co-culture and subsequent maturation in the presence of IL-21 generates tumor antigen-specific T cells with a favorable less-differentiated phenotype and enhanced functionality(2021)
Authors: Sarah Bonte, Stijn De Munter, Lore Billiet, Glenn Goetgeluk, Joline Ingels, Hanne Jansen, Melissa Pille, Laurenz De Cock, Karin Weening, Tom Taghon, et al.
- A novel non-coding variant in DCLRE1C results in deregulated splicing and induces SCID through the generation of a truncated ARTEMIS protein that fails to support V(D)J recombination and DNA damage repair(2021)
Authors: Steven Strubbe, Marieke De Bruyne, Ulrich Pannicke, Elien Beyls, Bart Vandekerckhove, Georges Leclercq, Elfride De Baere, Victoria Bordon, Anne Vral, Klaus Schwarz, et al.
- Conventional and computational flow cytometry analyses reveal sustained human intrathymic T cell development from birth until puberty(2020)
Authors: Marieke Lavaert, Bart Vandekerckhove, Georges Leclercq, Kai Ling Liang, Tom Taghon
- Intracellular delivery of mRNA in adherent and suspension cells by vapor nanobubble photoporation(2020)
Authors: Laurens Raes, Stephan Stremersch, Juan Fraire, Toon Brans, Glenn Goetgeluk, Stijn De Munter, Lien Van Hoecke, Rein Verbeke, Jelter Van Hoeck, Ranhua Xiong, et al.
- Human thymic CD10+ PD-1+ intraepithelial lymphocyte precursors acquire interleukin-15 responsiveness at the CD1a– CD95+ CD28– CCR7– developmental stage(2020)
Authors: Lore Billiet, Glenn Goetgeluk, Sarah Bonte, Stijn De Munter, Laurenz De Cock, Melissa Pille, Joline Ingels, Hanne Jansen, Karin Weening, Filip Van Nieuwerburgh, et al.
- T-cells with a single tumor antigen-specific T-cell receptor can be generated in vitro from clinically relevant stem cell sources(2020)
Authors: Sarah Bonte, Stijn De Munter, Glenn Goetgeluk, Joline Ingels, Melissa Pille, Lore Billiet, Tom Taghon, Georges Leclercq, Bart Vandekerckhove, Tessa Kerre