Researcher
Bart Vandekerckhove
- Keywords:Advanced therapy medicinal products, GMP, immunotherapy
- Disciplines:Other medical and health sciences not elsewhere classified, Adaptive immunology, Medicinal products not elsewhere classified, Cancer therapy
Affiliations
- Department of Diagnostic Sciences (Department)
Member
From1 Oct 2018 → Today - Department of Clinical chemistry, microbiology and immunology (Department)
Member
From1 Jan 1993 → 30 Sep 2018
Projects
21 - 30 of 30
- The role of the Wiskott-Aldrich Syndrome protein (WASp) in human T cell development and on the development of the T cell repertoire.From1 Jan 2017 → 31 Dec 2020Funding: FWO research project (including WEAVE projects)
- Improving outcome of immune checkpoint blockade in lung cancer by combination with a tumor mutanome-targeted dendritic cell vaccineFrom1 Jan 2017 → 31 Dec 2021Funding: Nonprofit institution or equivalents
- Improving outcome of immune checkpoint blockade in lung cancer by combination with a tumor mutanome-targeted dendritic cell vaccineFrom1 Jan 2017 → 31 Dec 2021Funding: Nonprofit institution or equivalents
- Improving outcome of immune checkpoint blockade in lung cancer by combination with a tumor mutanome-targeted dendritic cell vaccineFrom1 Jan 2017 → 31 Dec 2021Funding: Nonprofit institution or equivalents
- Generation of tumor-specific, single receptor CD4 helper and CDS cytotoxic cells from cord blood hematopoietic stem cells transgenic for a chimeric antigen receptor (CAR) incorporating a cytoplasmic costimulator domainFrom1 Jul 2015 → 30 Jun 2017Funding: Nonprofit institution or equivalents
- Yellow/Green laser upgrade for LSRII analyser and FACSARIAII sorter flow cytometersFrom15 Jun 2012 → 30 Jun 2016Funding: BOF - Other initiatives
- Study of human lymphoid cell differentiation using gene-modified embryonic stem cells and induced pluripotent stem cells from immunodeficiency patientsFrom1 Jan 2011 → 31 Oct 2015Funding: BOF - Concerted Research Project from 1994
- In vitro generation of cytotoxic T cells from CD34+ hematopoietic precursor cellsFrom1 Oct 2010 → 5 Jan 2016Funding: IWT personal funding - specialisation scholarships
- Generation and expansion of hematopoietic stem cells from human pluripotent stem cellsFrom1 Oct 2010 → 5 Jan 2016Funding: IWT personal funding - specialisation scholarships
- A flow cytometer to perform multiparameter sorting, including single-cell deposition under biohazard conditions L2From1 Jan 2009 → 31 Dec 2010Funding: BOF - Other initiatives
Publications
1 - 10 of 34
- Gene editing-based targeted integration for correction of Wiskott-Aldrich syndrome(2024)
Authors: Melissa Pille, John M. Avila, So Hyun Park, Cuong Q. Le, Haipeng Xue, Filomeen Haerynck, Lavanya Saxena, Ciaran Lee, Elizabeth J. Shpall, Gang Bao, et al.
- Single-cell profiling identifies a novel human polyclonal unconventional T cell lineage(2023)
Authors: Lore Billiet, Laurenz De Cock, Guillem Sanchez Sanchez, Rupert Mayer, Glenn Goetgeluk, Stijn De Munter, Melissa Pille, Joline Ingels, Hanne Jansen, Karin Weening, et al.
- Intrathymic dendritic cell-biased precursors promote human T cell lineage specification through IRF8-driven transmembrane TNF(2023)
Authors: Kai Ling Liang, Juliette Roels, Marieke Lavaert, Tom Putteman, Lena Böhme, Laurentijn Tilleman, Imke Velghe, Valentina Pegoretti, Inge Van de Walle, Stephanie Sontag, et al.
Pages: 474 - 486 - Transcriptional dynamics and epigenetic regulation of E and ID protein encoding genes during human T cell development(2022)
Authors: Juliette Roels, Jolien Van Hulle, Marieke Lavaert, Anna Kuchmiy, Steven Strubbe, Tom Putteman, Bart Vandekerckhove, Georges Leclercq, Filip Van Nieuwerburgh, Lena Böhme, et al.
- In vitro OP9-DL1 co-culture and subsequent maturation in the presence of IL-21 generates tumor antigen-specific T cells with a favorable less-differentiated phenotype and enhanced functionality(2021)
Authors: Sarah Bonte, Stijn De Munter, Lore Billiet, Glenn Goetgeluk, Joline Ingels, Hanne Jansen, Melissa Pille, Laurenz De Cock, Karin Weening, Tom Taghon, et al.
- A novel non-coding variant in DCLRE1C results in deregulated splicing and induces SCID through the generation of a truncated ARTEMIS protein that fails to support V(D)J recombination and DNA damage repair(2021)
Authors: Steven Strubbe, Marieke De Bruyne, Ulrich Pannicke, Elien Beyls, Bart Vandekerckhove, Georges Leclercq, Elfride De Baere, Victoria Bordon, Anne Vral, Klaus Schwarz, et al.
- Conventional and computational flow cytometry analyses reveal sustained human intrathymic T cell development from birth until puberty(2020)
Authors: Marieke Lavaert, Bart Vandekerckhove, Georges Leclercq, Kai Ling Liang, Tom Taghon
- Intracellular delivery of mRNA in adherent and suspension cells by vapor nanobubble photoporation(2020)
Authors: Laurens Raes, Stephan Stremersch, Juan Fraire, Toon Brans, Glenn Goetgeluk, Stijn De Munter, Lien Van Hoecke, Rein Verbeke, Jelter Van Hoeck, Ranhua Xiong, et al.
- Human thymic CD10+ PD-1+ intraepithelial lymphocyte precursors acquire interleukin-15 responsiveness at the CD1a– CD95+ CD28– CCR7– developmental stage(2020)
Authors: Lore Billiet, Glenn Goetgeluk, Sarah Bonte, Stijn De Munter, Laurenz De Cock, Melissa Pille, Joline Ingels, Hanne Jansen, Karin Weening, Filip Van Nieuwerburgh, et al.
- T-cells with a single tumor antigen-specific T-cell receptor can be generated in vitro from clinically relevant stem cell sources(2020)
Authors: Sarah Bonte, Stijn De Munter, Glenn Goetgeluk, Joline Ingels, Melissa Pille, Lore Billiet, Tom Taghon, Georges Leclercq, Bart Vandekerckhove, Tessa Kerre