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Researcher
Richard de Reuver
- Disciplines:Cell signalling, Virology, Autoimmunity, Epigenetics, Inflammation, Innate immunity, Infectious diseases, Cell death
Affiliations
- Department of Biomedical molecular biology (Department)
Member
From11 Feb 2019 → Today
Projects
1 - 1 of 1
- Study of the interplay between Z-form dsRNA and ADAR1: revealing the mechanisms that prevent autoinflammatory disease and mapping their interaction at the molecular level.From1 Nov 2020 → 10 Feb 2024Funding: BOF - doctoral mandates
Publications
1 - 3 of 3
- ADAR1 prevents autoinflammation by suppressing spontaneous ZBP1 activation(2022)
Authors: Richard de Reuver, Simon Verdonck, Evelien Dierick, Josephine Nemegeer, Eline Hessmann, Sadeem Ahmad, Maude Jans, Gillian Blancke, Filip Van Nieuwerburgh, Alexander Botzki, et al.
Pages: 784 - 789 - ADAR1 interaction with Z-RNA promotes editing of endogenous double-stranded RNA and prevents MDA5-dependent immune activation(2021)
Authors: Richard de Reuver, Bartosz Wiernicki, Katrien Staes, Ellen De Meester, Tuur Muyldermans, Alexander Botzki, Filip Van Nieuwerburgh, Peter Vandenabeele, Jonathan Maelfait
- Sensing of endogenous nucleic acids by ZBP1 induces keratinocyte necroptosis and skin inflammation(2020)
Authors: Michael Devos, Giel Tanghe, Barbara Gilbert, Evelien Dierick, Maud Verheirstraeten, Josephine Nemegeer, Richard de Reuver, Sylvie Lefebvre, Jolien De Munck, Jan Rehwinkel, et al.