Researcher
Jonathan Maelfait
- Keywords (Ghent University):antiviral immunity, nucleic acid immunity
- Disciplines (Flanders Institute for Biotechnology):Analysis of next-generation sequence data, Adaptive immunology, Bacteriology
- Disciplines (Ghent University):Molecular and cell biology, Laboratory medicine, Innate immunity, Medicinal and biomolecular chemistry, Microbiology
- See also: Jonathan Maelfait (Flanders Institute for Biotechnology)
Affiliations
- Vandenabeele Lab (Research group)
Member
From1 May 2018 → Today - Janssens Lab (Research group)
Member
From1 Mar 2018 → 30 Apr 2018 - Lambrecht and Hammad Lab (Research group)
Member
From1 Jan 2017 → 28 Feb 2018 - Department of Internal medicine (Department)
Member
From13 Dec 2016 → 30 Apr 2018 - Department of Biomedical molecular biology (Department)
Member
From1 Jan 2006 → Today
Projects
1 - 9 of 9
- Molecular and Functional Characterisation of Z-nucleic Acid-induced SignallingFrom1 Feb 2025 → TodayFunding: BOF - projects
- LNP-DECODE: Deciphering the adjuvants activity of lipid nanoparticle-based mRNA vaccines in primary dendritic cellsFrom1 Jan 2024 → TodayFunding: BOF - projects
- Role of ZBP1 signalling in doxorubicin-mediated anticancer immunity and drug-induced pathologyFrom1 Oct 2023 → TodayFunding: BOF - projects
- Genetic dissection of the immune pathways that cause Aicardi-Goutières Syndrome.From1 Jan 2022 → TodayFunding: FWO research project (including WEAVE projects)
- Cell Death Regulation and Role in Infection and Inflammatory DiseasesFrom1 Jan 2022 → TodayFunding: FWO EOS
- Study of the interplay between Z-form dsRNA and ADAR1: revealing the mechanisms that prevent autoinflammatory disease and mapping their interaction at the molecular level.From1 Nov 2020 → 10 Feb 2024Funding: BOF - doctoral mandates
- Sensing of viral Z-RNA by ZBP1From1 Jan 2019 → 31 Dec 2022Funding: FWO Strategic Basic Research Grant
- Study of Z-RNA in antiviral programmed cell death and immune dysregulationFrom1 May 2018 → TodayFunding: FWO Odysseus
- IRE1beta-mediated cell death pathways unraveledFrom1 Jan 2018 → 31 Dec 2018Funding: FWO research grant KAN
Publications
1 - 10 of 32
- The Z-nucleic acid sensor ZBP1 in health and disease(2023)
Authors: Jonathan Maelfait, Jan Rehwinkel
- Tyramide signal amplification for the immunofluorescent staining of ZBP1-dependent phosphorylation of RIPK3 and MLKL after HSV-1 infection in human cells(2022)
Authors: Josephine Nemegeer, Kelly Lemeire, Peter Vandenabeele, Jonathan Maelfait
- Reduced protection of RIPK3-deficient mice against influenza by matrix protein 2 ectodomain targeted active and passive vaccination strategies(2022)
Authors: Teodora-Eugenia Oltean, Lorena Ibanez, Tatyana Divert, Tine Ysenbaert, Hannelore Van Eeckhoutte, Michael Schotsaert, Jonathan Maelfait, Nozomi Takahashi, Peter Vandenabeele
- Mutations in RNU7-1 weaken secondary RNA structure, induce MCP-1 and CXCL10 in CSF, and result in Aicardi-Goutières syndrome with severe end-organ involvement(2022)
Authors: Leslie Naesens, Josephine Nemegeer, Filip Roelens, Lore Vallaeys, Marije Meuwissen, Katrien Janssens, PATRICK VERLOO, Benson Ogunjimi, Dimitri Hemelsoet, Levi Hoste, et al.
Pages: 962 - 974 - Viral manipulation of host cell necroptosis and pyroptosis(2022)
Authors: Simon Verdonck, Josephine Nemegeer, Peter Vandenabeele, Jonathan Maelfait
Pages: 593 - 605 - ADAR1 prevents autoinflammation by suppressing spontaneous ZBP1 activation(2022)
Authors: Richard de Reuver, Simon Verdonck, Evelien Dierick, Josephine Nemegeer, Eline Hessmann, Sadeem Ahmad, Maude Jans, Gillian Blancke, Filip Van Nieuwerburgh, Alexander Botzki, et al.
Pages: 784 - 789 - GTF3A mutations predispose to herpes simplex encephalitis by disrupting biogenesis of the host-derived RIG-I ligand RNA5SP141(2022)
Authors: Leslie Naesens, Santoshi Muppala, Dhiraj Acharya, Josephine Nemegeer, Delfien Bogaert, Jung-Hyun Lee, Katrien Staes, Veronique Debacker, Pieter De Bleser, Marieke De Bruyne, et al.
- Human ZBP1 induces cell death-independent inflammatory signaling via RIPK3 and RIPK1(2022)
Authors: Ruoshi Peng, Chris Kedong Wang, [missing] Xuan Wang-Kan, Manja Idorn, Majken Kjaer, Felix Y. Zhou, Berthe Katrine Fiil, Frederik Timmermann, Susana L. Orozco, Julia McCarthy, et al.
- ADAR1 interaction with Z-RNA promotes editing of endogenous double-stranded RNA and prevents MDA5-dependent immune activation(2021)
Authors: Richard de Reuver, Bartosz Wiernicki, Katrien Staes, Ellen De Meester, Tuur Muyldermans, Alexander Botzki, Filip Van Nieuwerburgh, Peter Vandenabeele, Jonathan Maelfait
- Viral dosing of influenza A infection reveals involvement of RIPK3 and FADD, but not MLKL(2021)
Authors: Teodora-Eugenia Oltean, Emily Van San, Tatyana Divert, Tom Vanden Berghe, Jonathan Maelfait, Nozomi Takahashi, Peter Vandenabeele