Researcher
Josephine Nemegeer
- Keywords:Z-RNA, VZV, ZBP1, Antiviral necroptosis
- Disciplines:Cell signalling, Virology, Inflammation, Innate immunity, Cell death
Affiliations
- Department of Biomedical molecular biology (Department)
Member
From6 Sep 2018 → 24 Sep 2023
Projects
1 - 1 of 1
- Sensing of viral Z-RNA by ZBP1From1 Jan 2019 → 31 Dec 2022Funding: FWO Strategic Basic Research Grant
Publications
1 - 7 of 7
- Tyramide signal amplification for the immunofluorescent staining of ZBP1-dependent phosphorylation of RIPK3 and MLKL after HSV-1 infection in human cells(2022)
Authors: Josephine Nemegeer, Kelly Lemeire, Peter Vandenabeele, Jonathan Maelfait
- Mutations in RNU7-1 weaken secondary RNA structure, induce MCP-1 and CXCL10 in CSF, and result in Aicardi-Goutières syndrome with severe end-organ involvement(2022)
Authors: Leslie Naesens, Josephine Nemegeer, Filip Roelens, Lore Vallaeys, Marije Meuwissen, Katrien Janssens, PATRICK VERLOO, Benson Ogunjimi, Dimitri Hemelsoet, Levi Hoste, et al.
Pages: 962 - 974 - Viral manipulation of host cell necroptosis and pyroptosis(2022)
Authors: Simon Verdonck, Josephine Nemegeer, Peter Vandenabeele, Jonathan Maelfait
Pages: 593 - 605 - ADAR1 prevents autoinflammation by suppressing spontaneous ZBP1 activation(2022)
Authors: Richard de Reuver, Simon Verdonck, Evelien Dierick, Josephine Nemegeer, Eline Hessmann, Sadeem Ahmad, Maude Jans, Gillian Blancke, Filip Van Nieuwerburgh, Alexander Botzki, et al.
Pages: 784 - 789 - GTF3A mutations predispose to herpes simplex encephalitis by disrupting biogenesis of the host-derived RIG-I ligand RNA5SP141(2022)
Authors: Leslie Naesens, Santoshi Muppala, Dhiraj Acharya, Josephine Nemegeer, Delfien Bogaert, Jung-Hyun Lee, Katrien Staes, Veronique Debacker, Pieter De Bleser, Marieke De Bruyne, et al.
- Clinical, genetic and immunological evaluation of the type I interferonopathy Aicardi-Goutieres syndrome caused by mutations in RNU7-1(2021)Volume: 76
Authors: Leslie Naesens, Josephine Nemegeer, Rudi Beyaert, Jonathan Maelfait, Filomeen Haerynck
Pages: 27 - 27 - Sensing of endogenous nucleic acids by ZBP1 induces keratinocyte necroptosis and skin inflammation(2020)
Authors: Michael Devos, Giel Tanghe, Barbara Gilbert, Evelien Dierick, Maud Verheirstraeten, Josephine Nemegeer, Richard de Reuver, Sylvie Lefebvre, Jolien De Munck, Jan Rehwinkel, et al.