Liver progenitor cell biology in chronic liver disease. Vrije Universiteit Brussel
regenerative capacity. Unfortunately, this hepatocytic regeneration does not last forever. Severe acute or chronic liver injury leads to hepatocyte senescence which results in the activation of another epithelial cell type, called a liver progenitor cell (LPC). These adult stem cells are capable to proliferate unlimited source of new liver cells. However, mechanisms involved in their differentiation and participation in liver regeneration are ...