Publicaties
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Clinical and preclinical studies of modulators of high-risk prostate cancer with metastatic potential KU Leuven
The overarching aim of this dissertation is to contribute to both clinical and preclinical knowledge of high-risk localized prostate cancer (PCa). It is currently accepted that high-risk PCa patients need radical treatment in an attempt to cure their disease. However, there are still important questions related to both oncological and functional outcomes that need to be addressed: - Currently, the EAU PCa guidelines recommend both ...
Proteolysis of systemic autoantigens and suppression of systemic autoimmunity by gelatinase B/MMP-9 KU Leuven
Bij de mens omvat de familie van de matrix metalloproteïnasen (MMPs) 24verschillende neutrale endopeptidasen. Deze proteasen komen tussen infysiologische processen zoals reproductie, ontwikkeling, immuniteit enweefselherstel. Ontregeling van MMP activiteit heeft echter pathogene effecten bij kanker, inflammatie, vasculaire ziekten, neurodegeneratieve aandoeningen en auto-immuunziekten. Gelatinase B/MMP-9 wordt vooral gesecreteerd door ...
Chemogenetic seizure control with clozapine and the novel ligand JHU37160 outperforms the effects of Levetiracetam in the intrahippocampal kainic acid mouse model Universiteit Gent
Inhibitory actions of the NRG-1/ErbB4 pathway in macrophages during tissue fibrosis in heart, skin and lung Universiteit Antwerpen
The neuregulin-1 (NRG-1)/ErbB system is an endothelium-controlled paracrine system modulating cardiac performance and adaptation. Recent studies indicate that NRG-1 has anti-fibrotic effects in the left ventricle (LV), which were explained by direct actions on cardiac fibroblasts. However, the NRG-1/ErbB system also regulates the function of macrophages. In this study, we hypothesized that the anti-fibrotic effect of NRG-1 in the heart is at ...
Retina pathology as a target for biomarkers for Alzheimer's disease: Current status, ophthalmopathological background, challenges, and future directions KU Leuven
There is emerging evidence that amyloid beta protein (Aβ) and tau-related lesions in the retina are associated with Alzheimer's disease (AD). Aβ and hyperphosphorylated (p)-tau deposits have been described in the retina and were associated with small amyloid spots visualized by in vivo imaging techniques as well as degeneration of the retina. These changes correlate with brain amyloid deposition as determined by histological quantification, ...
Primary retinal tauopathy: A tauopathy with a distinct molecular pattern KU Leuven
BACKGROUND: Phosphorylated tau (p-tau) accumulation, a hallmark of Alzheimer's disease (AD), can also be found in the retina. However, it is uncertain whether it is linked to AD or another tauopathy. METHODS: Retinas from 164 individuals, with and without AD, were analyzed for p-tau accumulation and its relationship with age, dementia, and vision impairment. RESULTS: Retinal p-tau pathology showed a consistent pattern with four stages and a ...
Pleiotropic effects of trisomy and pharmacologic modulation on structural, functional, molecular, and genetic systems in a Down syndrome mouse model KU Leuven
Down syndrome (DS) is characterized by skeletal and brain structural malformations, cognitive impairment, altered hippocampal metabolite concentration and gene expression imbalance. These alterations were usually investigated separately, and the potential rescuing effects of green tea extracts enriched in epigallocatechin-3-gallate (GTE-EGCG) provided disparate results due to different experimental conditions. We overcame these limitations by ...
CHICK EMBRYO PLATFORMS FOR PRECLINICAL EVALUATIONS OF PHARMACOLOGICAL EFFECTS: TAKING TUMOR VASCULAR DISRUPTING AGENTS (VDAs) AS EXAMPLES KU Leuven
The aim of the present doctoral thesis was to evaluate pharmacological effects of vascular-disrupting agents (VDAs) in preclinical studies using the chick embryo model. The chick embryo model complies well with the current replace-reduce-refine 3R's guidelines in animal experiments. It includes biomedical imaging and has demonstrated promising applicability for qualitative and quantitative investigations on pharmaceutical properties of VDAs. A ...