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Impact of chronic pulmonary infection with Pseudomonas aeruginosa on transfection mediated by viral and nonviral vectors Universiteit Gent
Non-viral delivery of RNA for therapeutic T cell engineering Universiteit Antwerpen
Adoptive T cell transfer has shown great success in treating blood cancers, resulting in a growing number of FDA-approved therapies using chimeric antigen receptor (CAR)-engineered T cells. However, the effectiveness of this treatment for solid tumors is still not satisfactory, emphasizing the need for improved T cell engineering strategies and combination approaches. Currently, CAR T cells are mainly manufactured using gammaretroviral and ...
Non-viral transfection technologies for next-generation therapeutic T cell engineering Universiteit Gent
Vitreous and neural retina are barriers for non-viral ocular gene therapy Universiteit Gent
Het belangrijkste doel van dit werk was na te gaan of intravitreale injectie van niet‐virale gentherapie partikels een geschikte methode is in het kader van oculaire gentherapie. Vermits onbeschermd pDNA onstabiel is in het glasvocht, dient het afleveren van pDNA via intravitreale injectie te gebeuren met behulp van een geschikte vector, zoals een lipoplex. Een goede techniek om de immobilisatie van de aangewende lipoplexen in het glasvocht ...
Small molecules convey big messages : boosting non-viral nucleic acid delivery with low molecular weight drugs Universiteit Gent
Optimized Parameters for Transducing the Locus Coeruleus Using Canine Adenovirus Type 2 (CAV2) Vector in Rats for Chemogenetic Modulation Research Vrije Universiteit Brussel Universiteit Gent
Introduction: The locus coeruleus noradrenergic (LC-NA) system is studied for its role in various neurological and psychiatric disorders such as epilepsy and Major Depression Dissorder. Chemogenetics is a powerful technique for specific manipulation of the LC to investigate its functioning. Local injection of AAV2/7 viral vectors has limitations with regards to efficiency and specificity of the transduction, potentially due to low tropism of ...