Publicaties
Inferring temporal motifs for travel pattern analysis using large scale smart card data Universiteit Antwerpen Universiteit Gent
Genome-Wide Identification of Mitogen-Activated Protein Kinase Gene Family across Fungal Lineage Shows Presence of Novel and Diverse Activation Loop Motifs KU Leuven
Motifs in weighted networks and their Hirsch subgraphs KU Leuven Universiteit Antwerpen
SIMIT : subjectively interesting motifs in time series Universiteit Gent
A million peptide motifs for the molecular biologist Vrije Universiteit Brussel
PDL1 Signals through Conserved Sequence Motifs to Overcome Interferon-Mediated Cytotoxicity Vrije Universiteit Brussel
PDL1 blockade produces remarkable clinical responses, thought to occur by T cell reactivation through prevention of PDL1-PD1 T cell inhibitory interactions. Here, we find that PDL1 cell-intrinsic signaling protects cancer cells from interferon (IFN) cytotoxicity and accelerates tumor progression. PDL1 inhibited IFN signal transduction through a conserved class of sequence motifs that mediate crosstalk with IFN signaling. Abrogation of PDL1 ...
hfAIM: A reliable bioinformatics approach for in silico genome-wide identification of autophagy-associated Atg8-interacting motifs in various organisms Instituut voor Tropische Geneeskunde Universiteit Gent
Most of the proteins that are specifically turned over by selective autophagy are recognized by the presence of short Atg8 interacting motifs (AIMs) that facilitate their association with the autophagy apparatus. Such AIMs can be identified by bioinformatics methods based on their defined degenerate consensus F/W/Y-X-X-L/I/V sequences in which X represents any amino acid. Achieving reliability and/or fidelity of the prediction of such AIMs on ...