Onderzoeker
Alexandre Wohlkönig
- Trefwoorden (Vrije Universiteit Brussel):Toegepaste biologische wetenschappen
- Disciplines (Flanders Institute for Biotechnology):(Bio)moleculaire modellering en design, Analytische biochemie, Medische biofysica
Affiliaties
- Structurele Biologie Brussel (Onderzoeksgroep)
Lid
Vanaf1 sep 2009 → Heden - Steyaert Lab (Onderzoeksgroep)
Lid
Vanaf1 jan 2017 → Heden - Toegepaste Biologische Wetenschappen (Departement)
Lid
Vanaf1 jul 2012 → 23 dec 2016 - Toegepaste Biologische Wetenschappen (Departement)
Lid
Vanaf1 jul 2012 → 23 dec 2016 - Toegepaste Biologische Wetenschappen (Departement)
Lid
Vanaf1 sep 2009 → Heden
Publicaties
1 - 10 van 24
- Nanobody Loop Mimetics Enhance Son of Sevenless 1-Catalyzed Nucleotide Exchange on RAS(2023)
Auteurs: K Van Holsbeeck, Baptiste Fischer, S Gonzalez, Charlène Gadais, Wim Versées, José Martins, Charlotte Martin, Alexandre Wohlkönig, Jan Steyaert, Steven Ballet
Pagina's: 1-6 - Downsizing Nanobodies: Towards CDR3 Loop Mimetics Modulating Intracellular Protein-Protein Interactions(2022)
Auteurs: Baptiste Fischer, S Gonzalez, Charlène Gadais, José C. Martins, Alexandre Wohlkönig
Pagina's: 141-142 - Megabodies expand the nanobody toolkit for protein structure determination by single-particle cryo-EM(2021)
Auteurs: Tomasz Uchański, Simonas Masiulis, Baptiste Fischer, Valentina Kalichuk, Uriel López-Sánchez, Eleftherios Zarkadas, Miriam Weckener, Andrija Sente, Philip Ward, Alexandre Wohlkönig, et al.
Pagina's: 60-68 - Fragment-Based Optimized EthR Inhibitors with in Vivo Ethionamide Boosting Activity(2020)
Auteurs: Baptiste Villemagne, Arnaud Machelart, Ngoc Chau Tran, Marion Flipo, Martin Moune, Florence Leroux, Catherine Piveteau, Alexandre Wohlkönig, René Wintjens, Xue Li, et al.
Pagina's: 366-378 - Methyl arachidonyl fluorophosphonate inhibits Mycobacterium tuberculosis thioesterase TesA and globally affects vancomycin susceptibility(2020)
Auteurs: Dong-Zi Yang, Guy Vandenbussche, Didier Vertommen, Damien Evrard, Romany Abskharon, Jean‐François Cavalier, Gilles Berger, Stéphane Canaan, Mohammad Khan, Sheng Zeng, et al.
Pagina's: 79-93 - A fragment-based approach towards the discovery of N-substituted tropinones as inhibitors of Mycobacterium tuberculosis transcriptional regulator EthR2(2019)
Auteurs: Hugues Prevet, Martin Moune, Abdalkarim Tanina, Christian Kemmer, Adrien Herledan, Rosangela Frita, Alexandre Wohlkönig, Marilyne Bourotte, Baptiste Villemagne, Florence Leroux, et al.
Pagina's: 426-438 - A comprehensive analysis of the protein-ligand interactions in crystal structures of Mycobacterium tuberculosis EthR(2019)
Auteurs: Abdalkarim Tanina, Alexandre Wohlkönig, Sameh Soror, Marion Flipo, Baptiste Villemagne, Hugues Prevet, Benoit Déprez, Martin Moune, Hélène Perée, Franck Meyer, et al.
Pagina's: 248-258 - An improved yeast surface display platform for the screening of nanobody immune libraries(2019)
Auteurs: Tomasz Uchański, Thomas Zögg, Jie Yin, Daopeng Yuan, Alexandre Wohlkönig, Baptiste Fischer, Daniel M. Rosenbaum, Brian K Kobilka, Els Pardon, Jan Steyaert
Pagina's: 1-12 - Structural analysis of the interaction between spiroisoxazoline SMARt-420 and the Mycobacterium tuberculosis repressor EthR2(2017)
Auteurs: Alexandre Wohlkönig, Han Remaut, Martin Moune, Abdalkarim Tanina, Franck Meyer, Matthieu Desroses, Jan Steyaert, Nicolas Willand, Alain R Baulard, René Wintjens
Pagina's: 403-408 - reverse resistance(2017)
Auteurs: Nicolas Blondiaux, Martin Moune, Matthieu Desroses, Rosangela Frita, Marion Flipo, Vanessa Mathys, Karine Soetaert, Mehdi Kiass, Vincent Delorme, Kamel Djaout, et al.
Pagina's: 1206-1211
Patenten
1 - 7 van 7
- Positive allosteric modulators of the calcium-sensing receptor (Inventor)
- Methods to select for agents that stabilize protein complexes (Inventor)
- Fusion proteins comprising a cytokine and scaffold protein (Inventor)
- Methods to select agents that stabilize protein complexes (Inventor)
- Means and methods for selection of specific binders (Inventor)
- Fusion proteins comprising a cytokine and scaffold protein (Inventor)
- Nanobody exchange chromatography (Inventor)