Projecten

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Utilization of molecular resistance test results as tools to support public health efforts for improved control of rifampicin resistant tuberculosis Instituut voor Tropische Geneeskunde

Frank G.J. Cobbelens, Bouke de Jong
Mycobacteriologie
The World Health Organization (WHO) has declared tuberculosis (TB) as the infectious disease with the highest mortality worldwide, resulting in 1.8 million deaths in 2015 despite development of potent antibiotics and vaccine [1, 2]. TB places its heaviest burden on the poorest and most vulnerable populations globally, aggravating existing inequity [3]. Management of the disease has been continually challenged by the emergence of antimicrobial ...

Molecular Reclassification to Find Clinically Useful Biomarkers for Systemic Autoimmune Diseases KU Leuven

Rik Lories
Onderzoekscentrum voor Skeletale Biologie en Engineering

We concur to the IMI on “Reclassification of SLE, connective tissue diseases and RA” call by presenting a proposal aimed at using the power of OMICs, and bioinformatics to identify new classifications for diseases known to share common pathophysiological mechanisms. Such knowledge has not been applied to individual patients, depriving them from potential benefits in terms of the use of new therapeutic agents that are being developed for one ...

'Molecular Imaging' onmoet 'Imaging Molecules' Universiteit Antwerpen

Sara Bals
Instituut voor Vaccin-en Infectieziekten (VAXINFECTIO), Bio-imaging, Elektronenmicroscopie voor materiaalonderzoek (EMAT)
Bij stamcelonderzoek speelt MRI beeldvorming een cruciale rol om te kunnen bepalen of toegediende stamcellen het doelwitorgaan bereiken, lokaal overleven, differentiëren en deel zullen uitmaken van het aangetaste weefsel. Echter, kennis m.b.t. de interactie van contrastpartikels met (sub)cellulaire structuren ontbreekt. In dit project zullen geavanceerde TEM technieken worden toegepast om verschillende types MRI contrastpartikels en ...

Molecular epidemiological approach to understand the emergence and spread of drug resistant Mycobacterium tuberculosis strains in Peru Instituut voor Tropische Geneeskunde

Jorge Arevalo, Leen Rigouts
Departement Biomedische Wetenschappen, Universiteit Antwerpen, Mycobacteriologie
Tuberculosis (TB) is a chronic infectious disease that remains a major health problem worldwide. It is more prevalent in underdeveloped and developing countries where it kills over 2 million people per year. One third ofthe world is thought to be infected by TB bacilli, and the World Health Organization estimates that nearly 1 billion additional people will become infected by M tuberculosis between 2000 and 2020 (36). In Latin America, Peru has ...

Estimating the effective reproductive rate of M. Tuberculosis from changes in molecular clustering rates, to measure the impact of public health interventions on TB transmission Instituut voor Tropische Geneeskunde

Bouke de Jong
Mycobacteriologie
Objectives

The major aim of the present proposal is to understand whether ECF has the ability to reduce transmission of TB in the intervention group when compared to the control group. To achieve this, the following objectives are defined:

Compare the proportion of TB-due-to-recent-transmission in intervention and control arms of a Cluster Randomized Trial on the impact of Enhanced Case Finding
a) Genotype isolates from intervention ...

Molecular adaptation of the tsetse fly transmited African trypanosome to the intradermal micro-environment in the mammalian host Instituut voor Tropische Geneeskunde

Jean-Claude Dujardin, Jan Van Den Abbeele
Veterinaire Protozoölogie
Human african trypanosomiasis (HAT), also known as sleeping sickness, is caused by the rhodesiense and gambiense subspecies of Trypanosoma brucei. HAT has a severe social and economic impact and, although the number of reported new cases are low and decreasing, it is still a major threat for 70 million people living in 1.55 M km2 of sub-Saharan Africa. Currently, despite of intensive research, an effective vaccine that can protect humans and/or ...

Strategic Research Programme: Molecular Imaging and TARgeting of Macrophages Vrije Universiteit Brussel

Tony Lahoutte
Cellulaire en Moleculaire Immunologie, Toegepaste Biologische Wetenschappen, Medische Beeldvorming, Translationele Beeldvorming Onderzoeksalliantie, Ondersteunende Klinische wetenschappen
Onderzoekt enerzijds de specifieke biologische vragen bij intact levende proefpersonen met behulp van niet-invasieve beeldvorming op basis van emissietomografie en optische beeldvorming in combinatie met anatomische beeldvorming (CT en MRI) en anderzijds de ontstekingen gekoppeld aan infectieziekten en kanker

Optimalisatie van de supramoleculare ordening om sterk Faraday actieve geconjugeerde polymeren te bekomen KU Leuven

Guy Koeckelberghs
Polymeerchemie en -materialen

De supramoleculaire ordening van het model geconjugeerde polymeer, poly(3-hexylthiofeen), wordt verbeterd in de hoop om de resulterende Faraday rotatie in films te verhogen. Dit wordt bereikt door de molaire massa, de dispersiteit en de endgroepen te variëren. Vervolgens worden verschillende monomeereenheden getest, zoals fluoreen en benzodithiofeen. Tenslotte worden de optimale parameters gecombineerd met een perfluoro-eindcapper en een ...