Publicaties
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Thrombospondin-2 prevents cardiac injury and dysfunction in viral myocarditis through the activation of regulatory T-cells. Vrije Universiteit Brussel
AIMS: Thrombospondin-2 (TSP-2) modulates matrix integrity and myocyte survival in the hypertensive or ageing heart. Whether TSP-2 may affect cardiac inflammation and injury, in particular during acute viral myocarditis, is completely unknown.
METHODS AND RESULTS: Therefore, mortality, cardiac inflammation, and function were assessed in TSP-2-null (KO) and wild-type (WT) mice in human Coxsackie virus B3 (CVB3)-induced myocarditis. ...
METHODS AND RESULTS: Therefore, mortality, cardiac inflammation, and function were assessed in TSP-2-null (KO) and wild-type (WT) mice in human Coxsackie virus B3 (CVB3)-induced myocarditis. ...
Thrombospondin-2 prevents cardiac injury and dysfunction in viral myocarditis through the activation of regulatory T-cells KU Leuven
AIM: Thrombospondin-2 (TSP-2) modulates matrix integrity and myocyte survival in the hypertensive or ageing heart. Whether TSP-2 may affect cardiac inflammation and injury, in particular during acute viral myocarditis, is completely unknown.Methods and ResultsTherefore, mortality, cardiac inflammation and function were assessed in TSP-2-null (KO) and wild type (WT) mice in human Coxsackie virus B3 (CVB3)-induced myocarditis. TSP-2 KO had an ...
Regulatory T-cells from pancreatic lymphnodes of patients with type-1 diabetes express increased levels of microRNA miR-125a-5p that limits CCR2 expression KU Leuven
Autoimmune type 1 diabetes (T1D) is thought to be caused by a defective immune regulation with regulatory T (Treg) cells playing a fundamental role in this process. Tolerance mechanisms depend on tunable responses that are sensitive to minor perturbations in the expression of molecules that can be carried out by multiple epigenetic mechanisms, including regulation by microRNAs. In this study, microRNA expression profile was investigated in Treg ...
CD4 T-cell activation and reduced regulatory T-cell populations are associated with early development of cataracts among HIV-infected adults in Uganda Instituut voor Tropische Geneeskunde
Regulatory T-cell stability and functional plasticity in health and disease KU Leuven
FOXP3-expressing regulatory T cells (Treg ) are indispensable for immune homeostasis and tolerance, and in addition tissue-resident Treg have been found to perform noncanonical, tissue-specific functions. For optimal tolerogenic function during inflammatory disease, Treg are equipped with mechanisms that assure lineage stability. Treg lineage stability is closely linked to the installation and maintenance of a lineage-specific epigenetic ...
Selective ERK activation suppresses inflammatory arthritis via tolerogenic dendritic cells and antigen-specific regulatory T cells Vrije Universiteit Brussel
OBJECTIVE: Most therapeutic treatments for autoimmune arthritis rely on immunosuppressive drugs which have side effects. Although a previous study by our group showed that specific ERK activation suppressed immune responses, its application in a therapeutic setting has never been tested. The aim of the present study was to define the ERK-dependent immunosuppressive mechanisms and apply selective ERK activation for the treatment of experimental ...
A metabolic gene survey pinpoints fucosylation as a key pathway underlying the suppressive function of regulatory T cells in cancer Universiteit Gent Vlaams Instituut voor Biotechnologie KU Leuven
A metabolic CRISPR-Cas9 screen reveals the important role of fucosylation in the suppressive function of Tregs. Measuring fucosylation in Tregs has the potential to aid in the discovery of relevant prognostic markers for cancer patients. Forkhead box P3 (Foxp3)-expressing regulatory T cells (Treg) are the guardians of controlled immune reactions and prevent the development of autoimmune diseases. However, in the tumor context, their increased ...
A metabolic gene survey pinpoints fucosylation as a key pathway underlying the suppressive function of Regulatory T cells in cancer. KU Leuven
Tregs are essential for the prevention of autoimmunity but they have deleterious consequences when recruited to tumor sites where they exert immunosuppressive pressure on anti-tumor immune cells resulting in a diminished anti-tumor immune response and poor patient prognosis. As Foxp3 remains the main Treg marker I will perform a state-of-the-art CRISPR/Cas9 in vitro screen to explore the metabolism of Tregs in a high throughput fashion and ...
Development of a cellular model to study CCR8 signaling in tumor-infiltrating regulatory T cells KU Leuven
The human CC chemokine receptor 8 (CCR8) is specifically expressed on tumor-infiltrating regulatory T cells (TITRs) and is a promising drug target for cancer immunotherapy. However, the role of CCR8 signaling in TITR biology and the effectiveness of CCR8 small molecule antagonists as TITR-targeting immunotherapy remain subjects of ongoing debate. In this work, we generated a novel cellular model of TITRs by culturing peripheral blood mononuclear ...