Projecten

Overall objective To assess the safety and efficacy of weekly iron and folic acid supplementation (WIFS) in young women of child-bearing age living in a highly malarious area in Africa. Primary objective To assess the impact of long-term weekly iron supplementation in young women of child-bearing age on P.falciparum malaria infection during early pregnancy. Secondary objectives 1. To assess the impact of weekly iron supplementation on: ? ...

Pregnant women are very susceptible to malaria infection and Malaria in Pregnancy (MiP) is a major cause of maternal anaemia and low birth weight (LBW) that leads to infant mortality, poor growth and development. In low transmission areas, malaria can become severe, resulting in maternal and foetal death. In sub-Saharan Africa (SSA) MiP is responsible for 8–14% of LBW, 3–8% of infant deaths, higher risk of post-partum haemorrhage and ...

On the eve of the introduction of long-term combination HIV prevention/contraception vaginal rings in Africa, we need to improve our knowledge about the attitude of women in Africa towards the ring and to assess the effect of the ring on the vaginal microbiome.

The overall aim of this trial is to provide data on the acceptability of the vaginal ring in Rwanda and on the effects of such ring on the vaginal microbiome. A clinical ...

General

To determine the safety and efficacy of 4 ACTs (amodiaquine-artesunate, AQ-AS, dihydroartemisinin-piperaquine, DHA-PQ, artemether-lumefantrine, AL, Mefloquine-artesunate, MQAS) when administered to pregnant women with P. falciparum infection during the second and the third trimester and collect explanatory variables for treatment failure (PCR-corrected) and for recurrent parasitaemia. Safety will be determined by ...

Glucose homeostasis, metabolomics and pregnancy outcomes after bariatric surgery: de GLORIA studie De prevalentie van obesitas en metabool syndroom blijft wereldwijd toenemen. Obesitas bij vrouwen is geassocieerd met infertiliteit en miskramen. Tijdens een zwangerschap gaat obesitas gepaard met onder andere een verhoogd risico op zwangerschapsdiabetes, macrosomie, keizersnede en pre-eclampsie. Voor vrouwen met een BMI van > 40kg/m² of een ...

Overall Goal: To identify artemisinin-based combination treatments (ACT) that can be safely and efficaciously used to treat women with malaria in their second and third trimester of pregnancy. This will be attained through the following strategies: 1. Research: To determine the safety and efficacy of 4 ACTs when administered to pregnant women during the second and the third trimester with P. falciparum infection and collect explanatory ...

The evolution in drug regulation of the last 50 years has left pregnant women and their fetuses orphaned. This is particularly problematic for cancer during pregnancy, which raises a difficult and conflicting medical ethical decision process and which has recently become increasingly frequent. In 2012 we published the first prospective study indicating that antenatal exposure to cancer treatment can overall be considered safe. Building on ...