Exploring species-specificity in TLR4/MD-2 inhibition with amphiphilic lipid a mimicking glycolipids Universiteit Gent Vlaams Instituut voor Biotechnologie
The Toll-like receptor 4 (TLR4)/myeloid differentiation factor 2 (MD-2) complex is a key receptor of the innate immune system and a major driver of inflammation that is responsible for the multifaceted defense response to Gram-negative infections. However, dysfunction in the tightly regulated mechanisms of TLR4-mediated signaling leads to the uncontrolled upregulation of local and systemic inflammation, often resulting in acute or chronic ...