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Mutations in LZTR1 drive human disease by dysregulating RAS ubiquitination Vlaams Instituut voor Biotechnologie Universiteit Gent KU Leuven
Spontaneous resolution of nonimmune hydrops fetalis in a fetus with TP63 gene mutation and LZTR1 gene variants KU Leuven
In cases of fetal hydrops, searching for an etiology is essential to evaluate the fetal prognosis and propose the most appropriate management.
Mutations in the ubiquitin ligase adaptor LZTR1 drive human disease by dysregulating RAS ubiquitination and signaling. Universiteit Gent
Identification of Ftr1 and Zrt1 as iron and zinc micronutrient transceptors for activation of the PKA pathway in Saccharomyces cerevisiae Vlaams Instituut voor Biotechnologie KU Leuven
The SlZRT1 Gene Encodes a Plasma Membrane-Located ZIP (Zrt-, Irt-Like Protein) Transporter in the Ectomycorrhizal Fungus Suillus luteus Vrije Universiteit Brussel Universiteit Hasselt
Zinc (Zn) is an essential micronutrient but may become toxic when present in excess. In Zn-contaminated environments, trees can be protected from Zn toxicity by their root-associated micro-organisms, in particular ectomycorrhizal fungi. The mechanisms of cellular Zn homeostasis in ectomycorrhizal fungi and their contribution to the host tree's Zn status are however not yet fully understood. The aim of this study was to identify and ...
Association of Left Ventricular Mass With the AGTR1 A1166C Polymorphism KU Leuven
BackgroundThe A1166C polymorphism is located within the microRNA-155 binding site of the human angiotensin II (Ang II) type-1 receptor (AGTR1) gene. The C allele interferes with the base-pairing complementariness between AGTR1 mRNA and microRNA-155 and thereby increases AGTR1 protein expression in vitro. We hypothesized that left ventricular (LV) mass is associated with the AGTR1 A1166C polymorphism.MethodsAmong 708 individuals (mean age, 49.4 ...
LETM1 haploinsufficiency causes mitochondrial defects in Wolf-Hirschhorn syndrome patient cells: implications for dissecting underlying pathomechanisms in this condition KU Leuven
AbstractWolf-Hirschhorn syndrome (WHS) represents an archetypical example of a contiguous gene deletion disorder; a condition comprising a complex set of developmental phenotypes with a multigenic origin. Epileptic seizures, intellectual disability, growth restriction, motor delay and hypotonia are significant co-morbidities in WHS. Haploinsufficiency of LETM1, which encodes an mitochondrial inner membrane protein functioning in ion transport, ...
¿La letra o el E/espíritu? Peumatología, espiritualidad y limitaciones de la reforma del derecho canónico KU Leuven
En este ensayo dedicado a Víctor Codina, SJ. el autor sostiene que, aunque la reforma del derecho canónico es importante tanto por razones prácticas (tenemos problemas) como por razones teológicas (las ideas necesitan la encarnación), la letra siempre necesita el espíritu como contrapartida; es decir, una mentalidad (espíritu) y el Espíritu Santo. Dado que, según el Credo, el Espíritu es vivificador activo (vivificans), nunca se puede ...