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Verhoogde concentratie van carcino-embryonaal antigeen bij een man met allergische broncho-pulmonale aspergillose KU Leuven
A 50-year-old man with bronchial asthma who suffered from a slightly productive cough, was referred to our hospital because of an elevated serum carcinoembryonic antigen (CEA) level. On admission he was suspected to bear a malignant neoplasm, but a complete investigation could not confirm this, while a diagnosis of allergic bronchopulmonary aspergillosis (ABPA) arose. A chest computed tomographic (CT) scan revealed bronchiectasis and hilar and ...
Opvolgingsonderzoek naar het voorkomen van astma en allergie in relatie tot milieufactoren bij kinderen uit het eerste generatie Steunpunt Milieu en Gezondheid Departement Omgeving
Astma is wereldwijd één van de meest voorkomende chronische aandoeningen (Pearce et al. 2007). De diagnose van astma is gebaseerd op klinische symptomen, zoals terugkerende periodes van ademnood, hoest en een beklemmend gevoel in de borst. Deze symptomen ontstaan door inflammatie van de luchtwegen. Er zijn verschillende vormen van astma die elk een eigen fenotype hebben (bv. allergische versus niet-allergische astma) en waarschijnlijk ook een ...
Interplay between regulatory T cells, innate lymphoid cells and airway epithelium in asthma. KU Leuven
Asthma is a common chronic respiratory disease affecting 5-15% of the population for all ages. Different asthma phenotypes exist. Allergic asthma is well-characterized and several murine allergic asthma models exist. However, about 50% of the adult asthma patients have non-allergic asthma, which is difficult to treat and can be triggered by environmental factors such as air pollution, infections and exercise. Murine models of non-allergic asthma ...
Simultane oralemijtenanafylaxie ("pancake syndrome") bij een vader en zijn dochter Universiteit Antwerpen
Oralemijtenanafylaxie (OMA), ook het pancake syndrome genoemd, is een aandoening die gekenmerkt wordt door (ernstige) allergische reacties ten gevolge van de inname van voedsel waarin bloem zit gecontamineerd met mijten. De kliniek van OMA is zeer verscheiden en wordt bepaald door de plaats en de mate van mastcellen/basofielendegranulatie en treedt doorgaans op binnen het uur na de ingestie. De meest voorkomende symptomen zijn kortademigheid, ...
Early-onset airway damage in early-career elite athletes: A risk factor for exercise-induced bronchoconstriction KU Leuven
Exercise-induced bronchoconstriction is present in 24.5% of 12-13 years old early-career elite athletes. Epithelial damage might be an early phase hallmark in the development of EIB, in the absence of overt cellular inflammation.
Mass spectrometry-based identification of new anti-Ly and known antisynthetase autoantibodies KU Leuven
OBJECTIVES: To discover new and detect known antisynthetase autoantibodies (ASAs) through protein immunoprecipitation combined with gel-free liquid chromatography-tandem mass spectrometry (IP-MS). METHODS: IP-MS was performed using sera of individuals showing features of antisynthetase syndrome (ASyS) without (n=5) and with (n=12) previously detected ASAs, and healthy controls (n=4). New candidate aminoacyl-tRNA-synthetase (ARS) autoantigens ...
Chlorine exposure and intensive exercise induces airway hyperreactivity in a 3-week murine exercise model KU Leuven
RATIONALE: Exercise-induced bronchoconstriction (EIB) is defined as acute narrowing of the airways during or immediately after exercise. EIB has a high prevalence in elite swimmers probably due to the high ventilation rate and exposure to the chlorine by-products. It is still puzzling which pathophysiological mechanisms drive EIB. OBJECTIVE: In this study, we evaluated airway hyperreactivity, permeability, integrity and inflammation in a murine ...
Innate Lymphoid Cells Are Required to Induce Airway Hyperreactivity in a Murine Neutrophilic Asthma Model KU Leuven
RATIONALE: Non-allergic asthma is driven by multiple endotypes of which neutrophilic and pauci-granulocytic asthma have been best established. However, it is still puzzling what drives inflammation and airway hyperreactivity (AHR) in these patients and how it can be treated effectively. Recently, a potential role of the innate immune system and especially the innate lymphoid cells (ILC) has been proposed. OBJECTIVE: In this study, we ...