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Transition metal-free approach for the late-stage benzylic $C(sp^{3})-H$ etherifications and esterifications

Tijdschriftbijdrage - Tijdschriftartikel

Herein, we report a transition metal-free approach for the regioselective functionalisation of benzylic C(sp3)-H bonds using alcohols and carboxylic acids as the nucleophiles. This approach provides a straightforward route for the synthesis of various benzylic ethers and esters to provide a wide generality of this system. Expediently, twelve pharmaceutically relevant compounds have been synthesized using this strategy.
Tijdschrift: Chemical communications
ISSN: 1359-7345
Volume: 58
Pagina's: 11454 - 11457
Jaar van publicatie:2022
Trefwoorden:A1 Journal article