Transition metal-free approach for the late-stage benzylic $C(sp^{3})-H$ etherifications and esterifications

Herein, we report a transition metal-free approach for the regioselective functionalisation of benzylic C(sp3)-H bonds using alcohols and carboxylic acids as the nucleophiles. This approach provides a straightforward route for the synthesis of various benzylic ethers and esters to provide a wide generality of this system. Expediently, twelve pharmaceutically relevant compounds have been synthesized using this strategy.

Publication year:2022

Keywords:A1 Journal article

Accessibility:Open