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Organisatie
Steyaert Lab
Research Group
Hoofdorganisatie:VIB-VUB Center for Structural Biology
Tijdsduur:1 jan 2017 → Heden
Organisatieprofiel:Exploiting nanobodies for drug discovery on difficult targets like GPCRs and on the engineering of nanobodies to be used in single particle cryo-EM and OMICs applications.
Trefwoorden:Molecular Biophysics, protein networks, Macromolecules, crystallography
Disciplines:Medicinale en biomoleculaire chemie, Biochemie en metabolisme, Biofysica
Huidige onderzoekers
1 - 10 of 22 results
- Jan Steyaert (Verantwoordelijke)
- Marjolijn Berghmans (Lid)
- Thomas Dal Maso (Lid)
- Phebe De Keyser (Lid)
- Babette Deckers (Lid)
- Baptiste Fischer (Lid)
- Galicia Christian (Lid)
- Danae Giakoumakis (Lid)
- Steven Janvier (Lid)
- Valentina Kalichuk (Lid)
Projecten
1 - 9 of 9
- Integrated Services for Infectious Disease Outbreak Research (ISIDORe)Vanaf1 feb 2022 → HedenFinanciering: Andere Eu-programma's en intiatieven
- VIB Grant for Steyaert Lab_Period:2022-01-01-2026-12-31Vanaf1 jan 2022 → HedenFinanciering: VOI - Projectmatig onderzoek
- GBA stabilization and activation through nanobodies and derived peptide mimetics in neuronal modelsVanaf1 sep 2021 → HedenFinanciering: Buitenl. stichtingen, fondsen e.d. met wet. oogmerk
- GBA1 stabilization through nanobodies : a versatile tool to improve wild type and mutant enzyme functionVanaf1 aug 2019 → 31 jan 2021Financiering: Buitenl. stichtingen, fondsen e.d. met wet. oogmerk
- Biochemical and structural characterization of LRRK2-specific nanobodiesVanaf27 jul 2019 → 26 jul 2021Financiering: Buitenl. stichtingen, fondsen e.d. met wet. oogmerk
- Application of novel nanobodies to existing LRRK2 biomarker assays for the segregation of affected patients in multiple cohorts of familial and idiopathic PDVanaf1 dec 2018 → 30 nov 2020Financiering: Buitenl. stichtingen, fondsen e.d. met wet. oogmerk
- Conformation-specific nanobodies for biochemical, functional and structural characterization of LRRK2Vanaf15 jun 2017 → 14 jun 2019Financiering: Buitenl. stichtingen, fondsen e.d. met wet. oogmerk
- VIB Grant for Steyaert Lab_Period:2017-01-01-2021-12-31Vanaf1 jan 2017 → 31 dec 2021Financiering: VOI - Projectmatig onderzoek
- Releasing the full potential of Instruct to expand and consolidate infrastructure services for integrated structural life science researchVanaf1 jan 2017 → 31 dec 2020Financiering: Andere Eu-programma's en intiatieven
Publicaties
21 - 30 van 113
- Entropic pressure controls the oligomerization of the Vibrio cholerae ParD2 antitoxin.(2021)
Auteurs: Gabriela Garcia Rodriguez, Yana Girardin, Ranjan Kumar Singh, Gopinath Muruganandam, Wim Versées, Remy Loris
Pagina's: 904-920 - Mutational analysis of the extracellular disulphide bridges of the atypical chemokine receptor ACKR3/CXCR7 uncovers multiple binding and activation modes for its chemokine and endogenous non-chemokine agonists(2018)
Auteurs: Martyna Szpakowska, Jan Steyaert
Pagina's: 299-309 - Structural basis of purine nucleotide inhibition of human uncoupling protein 1.(2023)
Auteurs: Thomas Zögg, Els Pardon, Jan Steyaert
Pagina's: eadh4251 - Structural and biochemical analysis of the dual-specificity Trm10 enzyme from Thermococcus kodakaraensis prompts reconsideration of its catalytic mechanism(2018)
Auteurs: Ranjan Kumar Singh, Lina Wauters, Wim Versées
Pagina's: 1080-1092 - Structural insight into the formation of lipoprotein-ß-barrel complexes.(2020)
Auteurs: Van-Son Nguyen, Han Remaut
Pagina's: 1019-1025 - The G-Protein Rab5A Activates VPS34 Complex II, a Class III PI3K, by a Dual Regulatory Mechanism.(2020)
Auteurs: Els Pardon, Jan Steyaert
Pagina's: 2205-2218 - Crystal structure of human serum albumin in complex with megabody reveals unique human and murine cross-reactive binding site.(2024)
Auteurs: Els Pardon, Jan Steyaert
Pagina's: e-pub - GABAA receptor signalling mechanisms revealed by structural pharmacology(2019)
Auteurs: Tomasz Uchanski, Els Pardon, Jan Steyaert
Pagina's: 454-459 - Structural analysis of the interaction between spiroisoxazoline SMARt-420 and the Mycobacterium tuberculosis repressor EthR2(2017)
Auteurs: Alexandre Wohlkönig, Han Remaut, Jan Steyaert
Pagina's: 403-408 - Nanobodies to study protein conformational states.(2020)
Auteurs: Tomasz Uchanski, Els Pardon, Jan Steyaert
Pagina's: 117-123