Onderzoeker
Charles De Bock
- Disciplines:Systeembiologie
Affiliaties
- Laboratorium voor Moleculaire Biologie van Leukemie (VIB-KU Leuven) (Afdeling)
Lid
Vanaf1 nov 2012 → 31 dec 2019
Projecten
1 - 1 of 1
- Samenwerking van TLX3 met epigenetische veranderingen in de ontwikkeling van T-cel acute lymfatische leukemieVanaf1 okt 2018 → 20 okt 2022Financiering: FWO mandaten
Publicaties
1 - 10 van 32
- Oncogenic cooperation in T-cell acute lymphoblastic leukemia: the role of TLX3 and TCF7-SPI1(2022)
Auteurs: Quentin Van Thillo, Jan Cools, Charles De Bock
- FAT1 cadherin controls neuritogenesis during NTera2 cell differentiation(2019)
Auteurs: Abdulrzag F Ahmed, Charles De Bock, Estelle Sontag, Hubert Hondermarck, Lisa F Lincz, Rick E Thorne
Pagina's: 625 - 631 - Safe targeting of T cell acute lymphoblastic leukemia by pathology-specific NOTCH inhibition(2019)
Auteurs: Charles De Bock, Inge Lodewijckx, Delphine Verbeke, David Nittner, Sofie Demeyer, James Dooley, Adrian Liston, Jan Cools, Bart De Strooper
- T-cell acute lymphoblastic leukemias express a unique truncated FAT1 isoform that cooperates with NOTCH1 in leukemia development(2019)
Auteurs: Charles De Bock, Mark Fiers, Jan Cools
Pagina's: E204 - E207 - A comprehensive inventory of TLX1 controlled long non-coding RNAs in T-cell acute lymphoblastic leukemia through polyA plus and total RNA sequencing(2018)
Auteurs: Simon Bornschein, Charles De Bock, Stein Aerts, Jan Cools
Pagina's: E585 - E589 - Malt1 self-cleavage is critical for regulatory Tcell homeostasis and anti-tumor immunity in mice(2018)
Auteurs: Rocco Stirparo, Youlia Lampi, Delphine Verbeke, Jan Cools, Peter Marynen, Charles De Bock, Simon Bornschein
Pagina's: 1728 - 1738 - The CCR4-NOT complex is a tumor suppressor in Drosophila melanogaster eye cancer models(2018)
Auteurs: Rocco Stirparo, Sofie Demeyer, Charles De Bock, Mardelle Atkins, Georg Halder, Bassem Hassan, Jan Cools
- Cooperative Enhancer Activation by TLX1 and STAT5 Drives Development of NUP214-ABL1/TLX1-Positive T Cell Acute Lymphoblastic Leukemia(2018)
Auteurs: Marlies Vanden Bempt, Sofie Demeyer, Michaël Broux, Jolien De Bie, Simon Bornschein, Ellen Geerdens, Charles De Bock, Jan Cools
Pagina's: 271 - + - Defining the molecular basis of oncogenic cooperation between TAL1 expression and Pten deletion in T-ALL using a novel pro-T cell model system(2018)
Auteurs: Simon Bornschein, Sofie Demeyer, Rocco Stirparo, Carmen Vicente, Ellen Geerdens, Bart Ghesquière, Stein Aerts, Jan Cools, Charles De Bock
Pagina's: 941 - 951 - Mutant JAK3 phosphoproteomic profiling predicts synergism between JAK3 inhibitors and MEK/BCL2 inhibitors for the treatment of T-cell acute lymphoblastic leukemia(2018)
Auteurs: Sandrine Degryse, Charles De Bock, Sofie Demeyer, Inge Govaerts, Simon Bornschein, Delphine Verbeke, Jan Cools
Pagina's: 788 - 800