Study of inducible glycome manipulation of CAR-T cells upon antigen exposure in the tumor environment Ghent University
Glycosylation is the modification of macromolecules with carbohydrate structures. These carbohydrate structures together make up a layer at the outside of all of our cells, which we call the glycocalyx, or cell surface glycome. This forest of carbohydrate structures is the first thing that a molecule or cell senses when approaching a mammalian cell. Recently, we have developed the necessary technology for Chimeric Antigen Receptor (CAR) ...