Projects
Nature-based coastal defense systems on waves-currents-seagrass interaction: interdisciplinary research on coastal and ecology engineering and marine biology Ghent University
Nature-based solutions that provide sustainable coastal protection using low environmental impact solutions are significant in the adaptation process towards global climate change. One opportunity of sustainable protection is offered by aquatic vegetation(seagrass, salt marshes, and mangroves) in the coastal zone, which is of high ecological value and provides natural coastal protection through attenuating waves, baffling currents and ...
Interlocking synthetic biology, systems biology and artificial intelligence to develop a more efficient metabolic engineering workflow: a highly efficient biotechnological production platform for monoclonal chitooligosaccharides. Ghent University
Today, synthetic biology (SynBio) and systems biology (SysBio) are developing at an unprecedented pace into major drivers of industrial biotechnology. Despite these recent advances, the transformation of wild type organisms into highly efficient microbial cell factories (MCFs) remains a truly daunting task due to the enormous complexity of microbial cells. Typically, to steer the strain engineering process a “Design-Build-Test-Learn” (DBTL) ...
Syn/SysBio4COS: Combining synthetic and systems biology to unlock the potential of the hexosamine biosynthesis pathway for chitooligosaccharide production Ghent University
Turning microorganisms into highly efficient microbial cell factories (MCFs) is a daunting process due to the enormous cellular complexity, i.e., the vast metabolic network superimposed by a multilevel regulatory layer and the fragmentary knowledge thereof. Typically, to steer the strain engineering process a “Design-Build-Test-Learn” (DBTL) cycle is iteratively run. In this project, to move more successfully through this cycle and, hence, ...
Elucidating causative genes and pathogenetic mechanisms in cancer: a systems biology approach. KU Leuven
Identification of the molecular networks involved in leaf growth through a systems biology approach Ghent University
Plant growth and the influence of the environment on this growth are important aspects of plant physiology. Despite the fundamental importance of plant growth little is known on the molecular networks that govern size and growth rate of organs such as leaves. This project aims to unravel the regulatory pathways that drive leaf growth in a systems biology approach.
Transcriptomics for a systems biology approach towards evidencebased immunomodulatory therapeutic strategies in current and novel viral epidemics KU Leuven
While HIV can be kept under control with proper antiviral treatment, there are no targeted antivirals for HTLV infections, and treatment currently relies on empirical use of immunomodulatory drugs. Many emerging infections are empirically treated with IFN before direct antivirals can be developed. A typical example is HCV, which is only recently curable in almost all patients with direct acting antivirals, while decades of empirical IFN ...
A systems biology approach for a comprehensive understanding of development and adaptation in Leishmania donovani. University of Antwerp
A systems biology approach for a comprehensive understanding of development and adaptation in Leishmania donovani. University of Antwerp
Artificial genetic systems with stereocontrolled sugar-phosphate backbone: towards advanced therapy and synthetic biology. KU Leuven
Deoxyribonucleic acid (DNA) and ribonucleic acid (RNA) are among the most remarkable biomolecules since they provide the molecular basis for all life through their unique ability to store and propagate genetic information. In this information system, the genetic alphabet is formed by 4 nucleobases, each appended to a sugar moiety. Phosphodiester linkages connect successive sugars in strands of variable lengths. Natural DNA and RNA are quickly ...