Projects
Vitamin D analogs in combination with palbociclib as treatment for triple-negative breast cancer – preclinical evaluation and pathway analysis KU Leuven
1,25(OH)2D3, the biological active form of vitamin D3, is an important regulator of calcium and phosphate homeostasis in the body. By binding to the vitamin D receptor (VDR) and subsequent heterodimerization with the retinoid X receptor (RXR), this complex will migrate to the nucleus and bind to vitamin D responsive elements (VDREs) in regulatory regions of target genes to regulate gene transcription. Next to calcium and phosphate ...
JoyfulJob: Evaluation of the effect of healthy(er) food in the work environment on the potential of employees VIVES
A systemic search for novel congenital disorders of Glycosylation type 1 (CDG-I), with a comprehensive evaluation of the clinical phenotypes. KU Leuven
Glycosylation is one of the most abundant protein modifications found in nature. It results from a meticulously orchestrated process involving numerous proteins for the assembly and modification of oligosaccharide chains, and their attachment onto proteins and lipids. The importance of glycosylation is illustrated by a group of diseases called Congenital Disorders of Glycosylation (CDG). To date, almost 100 distinct disorders have been ...
Monitoring and Evaluation of a mobile Clinical Decision Making Support System (CDMSS) intervention for frontline providers of maternal and neonatal care in the Eastern region (ER) of Ghana Institute of Tropical Medicine
Development of up-to-date measurement and evaluation protocols for odour and odour nuisance in Flemish intensive animal husbandry Research Institute for Agriculture, Fisheries and Food
The main aim of this project is to develop up-to-date measurement and evaluation protocols for odour and odour nuisance in Flemish intensive farming. We build knowledge and actualize procedures for odour sampling, measurement and evaluation of odour nuisance in light of the evolutions in animal husbandry since 2002. The procedures developed are then validated via odour measurements in practice ...
The evaluation of health care programs and organization. University of Antwerp
Design, synthesis and biological evaluation of novel ferroptosis and necroptosis inhibitors. University of Antwerp
Towards a better selection of systemic treatment for patients with ER-positive HER2-negative breast cancer: the use of prognostic and predictive markers in early and metastatic setting KU Leuven
Worldwide, breast cancer represents about 25% of all cancers in women. There is extensive research effort into this highly complex and heterogeneous disease comprising many different histological and molecular subtypes with luminal, oestrogen receptor (ER)-positive human epidermal growth factor receptor 2 (HER2)-negative tumours being the most frequent subtype. Even within this subtype, there is a lot of heterogeneity, which complicates ...
The temporal dynamics of emotion regulation: The role of emotion sensitivity and anticipation Ghent University
This project will focus on emotion regulation (ER), which is the ability to influence the experience and expression of emotions. Studies on ER typically focus on emotions during the presentation of an emotion eliciting event, but the knowledge that a negative event is approaching can already trigger initial negative feelings. Possibly, in some individuals, these initial negative emotions might facilitate dwelling on negative self-referential ...