Putting DNA nanotechnology to work: the art of DNA origami and DNA-only cascades paving the way towards innovative concepts in biosensing KU Leuven
The ability to specifically detect extremely low concentrations of targets, preferably in a reproducible and fast manner, is crucial for the detection and therapy of many diseases. These major challenges in the biosensing field in part originate from incomplete understanding of:
- the interaction between target and receptor molecules
- how the signal is triggered
In this project, we hypothesize that by exploring ...
Self-Assembly of Patchy Particles for Nanotechnology Applications. University of Antwerp
Temporally and spatially resolved multi-element information at the micro- and nano-scale: development of new analytical methods and their application to metallomics and nanotechnology Ghent University
To date, most ICP U+2013 mass spectrometers are equipped with a U+201Cscanning-typeU+201D mass analyzer (quadrupole filter, sector-field MS). In the case of short transient signals, this may restrict elemental analysis to a single-nuclide approach. Recently, a new type
Cancer is one of the major causes of death in our society. The anti-cancer drugs currently used in chemotherapy produce several side effects and, although fatal for almost all cells in a tumor, a small percentage of cells appear to resist the treatment. Therefore, it is urgent to design new therapies that specifically target these cells while causing no harm to healthy tissue. The resistance to multiple drugs is linked to the presence of ...
Bridging microscopy with nanotechnology and interactomics to probe the membrane microenvironment of distinct y-secretase complexes in cells and neurons and to identify complex-specific interactors KU Leuven
γ-Secretase processes amyloid precursor protein to generate amyloid peptides that play a key role in Alzheimer’s disease. γ-Secretase comes in different flavors due to the existence of different subunit homologues/isoforms. We hypothesize that this heterogeneity is reflected in distinct locations in the cell/neuron that might form a basis.
Spatial-temporal dissection of organelle-specific y-secretase interactomes using nanotechnology KU Leuven
From the moment Alzheimer’s disease (AD) causing mutations were discovered in the PSEN genes, its protein products, presenilins (PSEN), have been in the center of attention for AD research. While their function as the catalytic component of the tetrameric intramembrane protease, γ-secretase, was described, pieces of the puzzle started coming together. However, decades later, many questions remain about its biology, exact role in the ...
Development of novel "immune stealth" nanotechnology for gene therapy of hemophilia: pre-clinical validation and underlying mechanisms Vrije Universiteit Brussel
Immune stealth nanotechnology for gene therapy of hemophilia 'A': mechanisms and translational implications Vrije Universiteit Brussel
This results in the induction of antibodies, called "inhibitors", that inactivate FIX and increase ...
Developments in medical diagnostics, environmental monitoring, food safety and therapeutics require systems that make it possible to detect a wide range of molecules in a fast and easy, yet specific and sensitive manner. In light of these applications and driven by this demand, the field of biosensing has demonstrated huge potential. In spite of this potential, continuous improvements beyond the state of the art are necessary to help overcome ...