Establishing safety and efficacy of an improved Asparaginase in dog models: final preparation for Phase I clinical trial Ghent University
We designed a novel stabilized humanized asparaginase with clinically relevant pharmacokinetic properties that has significantly reduced toxicity, but similar anti-leukemic properties compared to the asparaginase formulations that are nowadays used in the clinic to treat pediatric and adult acute lymphoblastic leukemia (manuscript in preparation). This project aims to validate the safety and efficacy of our newly designed asparaginase in a ...