Determining the mode of tumor growth in melanoma by lineage tracing. KU Leuven
Melanoma is one of the most aggressive and treatment-resistant human cancers. The difficulty in treating melanoma is thought to stem from its high degree of heterogenity and plasticity. A major controversy in the field is whether melanoma, which does indeed comprise heterogeneous subpopulations of cancer cells with different biological properties, is hierarchically organized into nontumorigenic and tumorigenic cells that possess stem ...