Laboratory of Intravital Microscopy and Dynamics of Tumor Progression (VIB-KU Leuven)

The Scheele laboratory focuses on morphogenesis, homeostasis, and tumorigenesis of epithelial organs ranging from a cellular level to the organ scale. More specifically, the Scheele lab studies how healthy tissue architecture and environment prevent or promote the different steps of tumorigenesis. To study these highly dynamic processes, the Scheele lab utilizes and develops state-of-the-art imaging approaches, including 3D whole organ imaging and 4D intravital microscopy using imaging windows. These imaging tools are complemented with (spatial) omics approaches, as well as quantitative modeling to further elucidate the mechanisms of tissue transformation.