IDENTIFICATION AND VALIDATION OF DRUG-TARGET INTERACTIONS USING CRISPR/CAS-MEDIATED GENOME EDITING KU Leuven
Drug discovery and development are cornerstones of the pharmaceutical industry. However, these processes are difficult, time-consuming and costly. Many new drugs fail during clinical development due to insufficient demonstration of their clinical benefit and efficacy. One of the major reasons for this failing is the lack of robust understanding of a drug’s mechanism of action. In addition, phenotypic drug discovery is experiencing a revival ...