Researcher
Paul Coucke
- Disciplines:Genetically modified animals
Affiliations
- Department of Biomolecular Medicine (Department)
Member
From1 Oct 2018 → Today - Department of Pediatrics and medical genetics (Department)
Member
From1 Oct 2002 → 30 Sep 2018
Projects
1 - 10 of 12
- Identification of modifier genes responsible for the phenotypic variability in Osteogenesis Imperfecta (OI)- patients using zebrafish modelsFrom14 Feb 2024 → TodayFunding: BOF - doctoral mandates
- Cofunding core facility - Core Zebrafish Facility Ghent (Core ZFG)From1 Jul 2022 → TodayFunding: BOF - research organisations
- Comparison of editing, complementing or replacement of defective RNA molecules as a novel treatment method to overcome early embryonic developmental arrestFrom1 Oct 2021 → 14 Sep 2023Funding: FWO junior postdoctoral fellowship
- Genome-wide Epistasis for cardiovascular severity in Marfan StudyFrom1 Jan 2021 → TodayFunding: FWO research project (including WEAVE projects)
- Identification of the mechanisms underlying the inter- and intrafamilial phenotypic variability in Osteogenesis Imperfecta, using the zebrafish as a modelFrom1 Jan 2020 → TodayFunding: FWO research project
- Personalized functional genomics in Mendelian diseases: from DNA variants to clinical and bioethical implicationsFrom1 Jan 2015 → 30 Sep 2021Funding: BOF - Concerted Research Project from 1994
- Unraveling the molecular basis of congenital heart defectsFrom1 Jan 2015 → 31 Dec 2020Funding: FWO research project
- Zebrafish platform for testing pathogenicity of human disease-associated variantsFrom1 Jun 2014 → 30 Nov 2015Funding: IOF - Industrial Research Fund
- Study of the role of GLUT10 in cellular metabolism and growth factor signaling underlying developmental defects.From1 Jan 2013 → 31 Dec 2018Funding: FWO research project
- Localization, identification and functional characterization of disease genes for retinal dystrophies.From1 Jan 2009 → 30 Dec 2011Funding: FWO research grant KAN
Publications
1 - 10 of 41
- Identification of modifier genes underlying intra-familial phenotypic variability in zebrafish OI models using whole exome sequencing and linkage analysis(2023)Volume: 7
Authors: Tamara Jarayseh, Adelbert De Clercq, Toon Rosseel, Mauro Alessio Milazzo, Andy Willaert, Paul Coucke
Number of pages: 1 - A tapt1 knockout zebrafish line with aberrant lens development and impaired vision models human pediatric cataract(2022)
Authors: Tamara Jarayseh, Brecht Guillemyn, Hanna De Saffel, Jan Willem Bek, Sujatha Jagadeesh, Sofie Symoens, Fransiska Malfait, Delfien Syx, Filip Van Nieuwerburgh, Yannick Gansemans, et al.
Number of pages: 1 - Minocycline attenuates excessive DNA damage response and reduces ectopic calcification in pseudoxanthoma elasticum(2022)
Authors: Lukas Nollet, Matthias Van Gils, Andy Willaert, Paul Coucke, Olivier Vanakker
Pages: 1629 - 1638.e6 - CRISPR-SID : identifying EZH2 as a druggable target for desmoid tumors via in vivo dependency mapping(2021)
Authors: Thomas Naert, Dieter Tulkens, Tom Van Nieuwenhuysen, Joanna Przybyl, Suzan Demuynck, Matt van de Rijn, Mushriq Al-Jazrawe, Benjamin A. Alman, Paul Coucke, Kim De Leeneer, et al.
- Lrp5 mutant and crispant zebrafish faithfully model human osteoporosis, establishing the zebrafish as a platform for CRISPR‐based functional screening of osteoporosis candidate genes(2021)
Authors: Jan Willem Bek, Chen Shochat, Adelbert De Clercq, Hanna De Saffel, Annekatrien Boel, Juriaan Metz, Frans Rodenburg, David Karasik, Andy Willaert, Paul Coucke
Pages: 1749 - 1764 - Correcting a PLCζ mutation in the human germ line to overcome hereditary infertility(2021)Volume: 36
Authors: Bieke Bekaert, Annekatrien Boel, Mina Popovic, Panagiotis Stamatiadis, S M Chuva de Sousa Lopes, Petra De Sutter, Björn Menten, Dominic Stoop, Paul Coucke, Björn Heindryckx
Pages: 11 - 11 - Rare modifier variants alter the severity of cardiovascular disease in pseudoxanthoma elasticum : identification of novel candidate modifier genes and disease pathways through mixture of effects analysis(2021)
Authors: Eva De Vilder, Ludovic Martin, Georges Lefthériotis, Paul Coucke, Filip Van Nieuwerburgh, Olivier Vanakker
- Identification of skeletal deformities towards deep phenotyping of zebrafish (Danio rerio) connective tissue disease models(2021)Volume: 14
Authors: Caitlin Debaene, Adelbert De Clercq, Andy Willaert, Paul Coucke
Number of pages: 1 - PCR based target enrichment for variant confirmation, gene panels and multiplex PCR sample tracking in a whole exome sequencing workflow(2019)Volume: 27
Authors: Frauke Coppieters, Thalia Van Laethem, Matthias De Smet, Paul Coucke, Elfride De Baere, Kathleen Claes, Björn Menten, Jo Vandesompele, Steve Lefever
Pages: 1660 - 1661 - Vascular Ehlers-Danlos syndrome in 2 Polish patients : identification of 2 novel COL3A1 gene mutations(2019)
Authors: Malgorzata Konieczynska, Ewa Wypasek, Marek Karpinski, Monika Komar, Sofie Symoens, Paul Coucke, Anetta Undas
Pages: 1070 - 1073