Mechanisms of the delayed-oxygen uptake kinetics and reduced exercise tolerance in type 2 diabetics. Ghent University
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The signal transduction involved in the positive inotropic and chronotropic answer to stimulation of the 5-HT4-receptors on the cardiac myocytes is investigated, in particular the intracellular compatimentalisation through phosphodiesterases and protein kinase A anchoring proteins (AKAPs). In the colon this is evaluated for the different cell types possessing 5-HT4-receptors (cholinergic neurons, nitrergic neurons, smooth muscle cells).
This project aims to develop a general strategy to implement and validate PAT systems in pharmaceutical production processes, allowing real-time release of the end product. Herewith, major attention is paid to the necessary use of complimentary PAT tools: in-line and real-time process analyzers (especially spectroscopic techniques), chemometrics, process control tools and knowledge management tools.
In their trichomes, Artemisia annua L. synthesises little amounts of artemisinin, active against malaria. The aim is to identify the genes that are involved in the biosynthesis of artemisinin and the formation of trichomes. This to create A. annua cultivars with an increased artemisinin production or to modify yeast to produce artemisinin.
The goal of this project is to achieve repopulation of biolocial aortic hearth matrices in order to obrain a vial tissue-engineerded construct that could serve as prototype for a tissue engineered heart valve. Four main sub objectives can be defined: (1) matrix optimalization, (2) Incorporation of growth factors in the biological matrix (3) Repopulation of the growht factor loaded matrices, '4) In vivo evaluation of tissue engineerded heart ...
For in vivo application of therapeutic siRNA, effective delivery is still defined as the major hurdle to overcome. Also, appropriate attention should be paid to optimize the gene silencing effect, both in terms of magnitude and duration. The major focus of this project is therefore the design of dextran nanogels for intracellular controlled release of siRNA.