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Project
Dipeptidyl peptidases beyond glucose homeostasis: from biochemistry to physiological importance.
This project aims to better understand the effects of chronic dipeptidyl peptidase (DPP) inhibition on pre-defined aspects of cardiovascular, renal and bone (patho)physiology. Inhibitors with defined selectivity profiles will be developed as tools. Expression and inhibition of DPP4 and related peptidases will be studied on the molecular level, in cultured cells and in rat models of ischemia/reperfusion injury of heart and kidney.
Date:1 Jan 2009 → 31 Dec 2012
Keywords:DIPEPTIDYL PEPTIDASE, CD26, INHIBITORS, ISCHEMIA
Disciplines:Biochemistry and metabolism, Systems biology, Medical biochemistry and metabolism, Biomarker discovery and evaluation, Drug discovery and development, Medicinal products, Pharmaceutics, Pharmacognosy and phytochemistry, Pharmacology, Pharmacotherapy, Toxicology and toxinology, Other pharmaceutical sciences