Projects
High-intensity interval training in diabetic cardiomyopathy: from molecular changes towards clinical benefits Hasselt University
CARdiomyopathy in type 2 DIAbetes mellitus KU Leuven
A rapidly evolving epidemic in Type 2 Diabetes (T2DM) is afflicting all ages, sexes and socioeconomic classes which includes serious comorbidities such as heart diseases. While ischaemic heart disease represents the major cause of death of T2DM patients, heart failure (80% of Heart Failure with preserved Ejection Fraction) is the second most common cardiovascular disease in T2DM patients. The aim of CARDIATEAM is to determine whether T2DM ...
From Onco to Cardio: AGEs as a new target for chemotherapyinduced cardiotoxicity. Hasselt University
Chemotherapy-induced cardiotoxicity: time for a chAnGE of stRAteGiEs. Hasselt University
Lipoprotein-targeted therapies for lipotoxic heart disease KU Leuven
Overwhelming epidemiological evidence shows that diabetes mellitus is independently associated with heart failure incidence, with the risk being increased by more than twofold in men and by more than fivefold in women. The most prevalent phenotype of heart failure in patients with obesity and diabetes mellitus is heart failure with preserved ejection fraction (HFpEF) (ejection fraction ≥50%)2. Inflammation has been proposed to be the primary ...
Towards new therapeutic areas for HDL-targeted interventions KU Leuven
Improving monitoring of cardiac function in critical illness: from advanced echocardiographic technology to metabolic and biochemical biomarkers predicting myocardial dysfunction. KU Leuven
Chapter 1: Validation of a deep neural network which integrates segmentation and as well as deformation imaging analysis in a large image database of echocardiograms. The objective of this chapter is to optimize deep learning techniques through study of a modified neural network, currently in development by the team of Jan D’hooge. This modified neural network will integrate local morphology of the myocardium derived from automated ...
Exercise epigenomics: microRNA as biomarker of exercise-induced cardiovascular adaptation. University of Antwerp
"-omics" as tool to address the burden of non-communicable age-related disease in populations in epidemiological transition KU Leuven
Summary
Background and objectives
The objective of this doctoral thesis was to explore “‑omics” technologies as a tool to address the burden of non-communicable age-related disease in populations in epidemiological transition. We choose diastolic left ventricular (LV) dysfunction, heart failure (HF) and chronic kidney disease (CKD) as disease models, because of their high prevalence in the general population, ...