Projects
A Pharmacometrics Approach to Improve Dose Individualisation Methods of Biologicals in Patients with Chronic Inflammatory Diseases KU Leuven
In clinical drug development, “one dose fits all” is a key objective. However, variability in exposure and thus response is common and can result in suboptimal treatment of individual patients. To hit a predefined exposure target in each patient, “therapeutic drug monitoring” (TDM) is often implemented. TDM helps improving attainment of a desired exposure target by guiding individualised drug dosing based upon drug concentrations. “Population ...
A Pharmacometrics Approach to Guide Dose Optimization of anti-infective drugs in special patient populations KU Leuven
In drug development, “one dose fits all” is a key objective. However, variability in exposure, is common and can result in suboptimal treatment of individual patients. To hit a predefined exposure target in each patient, therapeutic drug monitoring (TDM) is often implemented. TDM helps improving attainment of a desired target by guiding individualized dosing based on drug concentrations. Population pharmacokinetic (popPK) models can be used ...
Monitoring and intervening travel behavior of CVD patients Hasselt University
Out of limbo: a toolbox to eliminate ambiguity around HDAC6, offering a novel therapeutic opportunity against multiple myeloma. Ghent University
HDAC6 is an enzyme with a wide variety of substrates and interaction partners, which makes it an important regulator of diverse cellular processes and, in case of aberrant function, an actor in several diseases including cancer, neurodegenerative disorders and inflammation. Therefore, inhibitors have been developed to selectively target HDAC6. However, these compounds only target the deacetylase catalytic cavity, while also a ubiquitin ...
Optimized Plastics Recycling from Waste Electric and Electronic Equipment (WEEE) through Product Clustering KU Leuven
Waste electric and electronic equipment (WEEE) is a large and increasing waste stream. To attain recycling targets set by the European Union, recycling of WEEE plastics is a necessity. The complexity of the polymeric composition of the stream and the possible presence of hazardous substances are substantial challenges in WEEE plastics recycling.
In this dissertation, the use of product clusters for improved recycling of ...
Greening intensive farming landscapes: evaluating land use strategies in terms of biodiversity and ecosystem service provisioning and their tradeoffs with production and farmer income KU Leuven
Throughout history, European landscapes have been strongly influenced by farming practices. As a result, extensively managed farming landscapes provided a habitat to many species and nowadays, semi-natural habitats form the focus of nature conservation in Europe. During the past century, these farming landscapes became increasingly intensified, increasing food production levels throughout the region. However, the intensification of ...
MEANS TO REDUCE RADIOTHERAPY-RELATED TOXICITY FOR HEAD AND NECK SQUAMOUS CELL CARCINOMA KU Leuven
Head and neck cancers include malignancies originating in the oral cavity, nasopharynx, oropharynx, hypopharynx and larynx. In Belgium, more than 90 % of head and neck cancers are squamous cell carcinomas (HNSCC), and more than 2500 patients were diagnosed with HNSCC in the year 2016. (Belgium Cancer Registry) The use of alcohol and tobacco, with a substantial synergistic effect, induces most HNSCC except for oropharyngeal (OPC) and ...