Researcher
Matthias D'hooghe
- Disciplines:Organic chemical synthesis, Medicinal chemistry
Affiliations
- Department of Green Chemistry and Technology (Department)
Member
From1 Jan 2018 → Today - Department of Sustainable Organic Chemistry and Technology (Department)
Member
From1 Sep 2001 → 31 Dec 2017
Projects
1 - 10 of 31
- Development of hybrid molecules targeting glucocorticoid and peroxisome proliferator-activated receptor-based heterodimers to combat inflammationFrom1 Nov 2023 → TodayFunding: BOF - doctoral mandates
- Development of steroid-based GR-PPARα conjugates for the treatment of chronic inflammatory diseasesFrom1 Oct 2023 → TodayFunding: BOF - projects
- Out of limbo: a toolbox to eliminate ambiguity around HDAC6, offering a novel therapeutic opportunity against multiple myeloma.From1 Apr 2023 → 30 Apr 2023Funding: BOF - doctoral mandates
- Purchase of LC-MS equipment for the analysis of organic compounds, reaction mixtures and natural extractsFrom15 Dec 2022 → TodayFunding: BOF - scientific equipment program
- Curcumin-derived functionalized thiazepanes to selectively target colon cancer cellsFrom1 Nov 2022 → TodayFunding: FWO Strategic Basic Research Grant
- Validation of a small molecule system for a safer treatment of chronic inflammationFrom15 Jul 2022 → TodayFunding: IOF - technology validation in lab
- Design and development of carbapenem- and cephalosporin-based monocyclic beta-lactam derivatives to address antibiotic-insensitive penicillin-binding proteinsFrom1 Jan 2022 → TodayFunding: FWO research project (including WEAVE projects)
- Curcumin-derived functionalized thiazepanes to selectively target colon cancer cellFrom1 Oct 2021 → 31 Oct 2022Funding: BOF - doctoral mandates
- Purchase of GC-MS equipment for the analysis of volatile organic compounds.From1 Dec 2020 → 30 Nov 2022Funding: BOF - scientific equipment program
- From thiazepane curcuminoid hit structures to new anticancer lead compoundsFrom1 Oct 2020 → TodayFunding: BOF - projects
Publications
1 - 10 of 163
- High-yield synthesis of 2-O-α-d-glucosyl-d-glycerate by a bifunctional glycoside phosphorylase(2024)
Authors: Jorick Franceus, Manon Steynen, Yentl Allaert, Kato Bredael, Matthias D'hooghe, Tom Desmet
- Synthesis of 4‐imidoyl‐, 4‐oxiranyl‐ and 4‐propargyloxyphenyl‐substituted β‐lactam building blocks(2023)
Authors: Sari Deketelaere, Gurkirat Kaur, Nicola Piens, Daan Deturck, Robin Depestel, Kristof Van Hecke, Christian Stevens, Vipan Kumar, Matthias D'hooghe
Pages: 423 - 430 - The zinc-binding group effect : lessons from non-hydroxamic acid vorinostat analogs(2023)
Authors: Silke Geurs, Dorien Clarisse, Karolien De Bosscher, Matthias D'hooghe
Pages: 7698 - 7729 - Synthesis of the 1,5-benzothiazepane scaffold : established methods and new developments(2023)
Authors: Ulrike Ronse, Katarina Magdalenic, Matthias D'hooghe
- Engineering Comamonas testosteroni for the production of 2-pyrone-4,6-dicarboxylic acid as a promising building block(2023)
Authors: Tom Delmulle, Stijn Bovijn, Sari Deketelaere, Martijn Castelein, Tom Erauw, Matthias D'hooghe, Wim Soetaert
- Covalent organic framework supported palladium catalysts(2022)
Authors: Hadi Salemi, Maarten Debruyne, Pascal Van Der Voort, Matthias D'hooghe, Christian Stevens
Pages: 20707 - 20729 - Identification of mercaptoacetamide-based HDAC6 inhibitors via a lean inhibitor strategy : screening, synthesis, and biological evaluation(2022)
Authors: Freya Baele, Jorick Franceus, Matthias D'hooghe
Pages: 6239 - 6242 - The ubiquitin binding domain of HDAC6 : a key regulator of aggresomal protein disposal and new therapeutic target to combat multiple myeloma(2022)
Authors: Silke Geurs, Dorien Clarisse, Eleni Staessens, Karolien De Bosscher, Matthias D'hooghe
Number of pages: 1 - Unexpected formation of 2,2‐Dichloro‐N‐(chloromethyl)acetamides during attempted Staudinger 2,2‐Dichloro‐β‐lactam synthesis(2021)
Authors: Sari Deketelaere, Elias Van Den Broeck, Lore Cools, Daan Deturck, Hannes Naeyaert, Kristof Van Hecke, Christian Stevens, Matthias D'hooghe
Pages: 5823 - 5830 - Evolution of phosphorylases from N-acetylglucosaminide hydrolases in family GH3(2021)
Authors: Jorick Franceus, Jolien Lormans, Lore Cools, Matthias D'hooghe
Pages: 6225 - 6233
Patents
1 - 2 of 2
- Selective HDAC6 inhibitors and uses thereof (Inventor)
- HDAC6 Inhibitors and uses thereof (Inventor)