Unravelling the molecular programs that control the de novo formation of high endothelial venules KU Leuven
Lymph nodes and other secondary lymphoid organs (SLOs) are important immune response centers in which adaptive immune cells are recruited to acquire an activated and mature phenotype. Such lymphocyte trafficking is facilitated by high endothelial venules (HEV), specialized blood vessels that serve as major entry portals to coordinate lymphocyte infiltration. HEVs can also be induced in non- lymphoid organs at sites of chronic inflammation or ...