Projects
Quantifying and reducing uncertainty in structural dynamics. KU Leuven
This project aims to quantify and reduce uncertainty in numerical predictions for vibration problems in the built environment.
Efficient solution of fluid-structure interaction problems in structural dynamics Ghent University
In this project computational methods will be developed that can be used for fluid-structure interaction computations for rather slender and lightweight structures under wind loading conditions. This computational technique will allow for studies of ovalling of silos, flutter of bridges, excitation of flexible pipes by vortex shedding, galopping of cables, U+2026
Exploring excited state structural dynamics of fluorescent proteins by using X-ray free electron laser (XFEL) towards advancement of cutting‐edge microscopy KU Leuven
Structural dynamics basis of function in the SecB chaperone KU Leuven
How chaperones act on their clients remains a major universal unresolved issue and modulate folding pathways in ways that are still debatable. Some of them are proposed to act as 'holdases' that tightly bind to polypeptides and others like true 'foldases' providing active contribution to the folding process. In the secretory pathway the role of chaperones is critical as secretory polypeptides need to remain non-folded for several seconds in ...
Structural dynamics of secretory protein sorting, targeting, translocation (DynamicSTarT) KU Leuven
component is the Sec translocase, a nanomachine that recognizes exported proteins and takes them out of cell membranes. Pathogenic bacteria use the Sec system to export proteins such as toxins. To control pathogenicity and exploit it for biopharmaceuticals production we need to understand how it works. Scientists have identified Sec components and we have previously determined essential novel signals that allow exported proteins to find it. ...
Bcl-2/IP3R channel structural dynamics underlying complex formation, function and disease (BInamics) KU Leuven
Anti-apoptotic Bcl-2 proteins not only act the mitochondria where they prevent the release of pro-cell death factors but also function at the endoplasmic reticulum (ER), the organelle that serves as the main calcium-storage site in mammalian cells. At the ER, Bcl-2, via its “BH4 domain”, directly inhibits the IP3 receptor, a large calcium-release channel, preventing mitochondrial Ca2+ overload and thus cell death to occur. Previous studies ...
Structural dynamics of nanoalloys in catalytic reaction Ghent University
Atomic scale studies of Ni-Fe-based nanoalloys for CO2 utilization, e.g. CH4 or biogas dry reforming and methanation, will be performed to identify the local structure and electronic state during reaction. Characterization methods with high surface sensitivity and advanced modelling techniques will be employed. This study will offer guidelines to fine-tune the alloys’ properties along the requirements of a catalytic reaction.
Structural dynamics of the oil market Ghent University
We study time variation in oil market dynamics.