Projects
Structural dynamics of the protein translocase motor KU Leuven
More than a third of cellular proteins are secreted from the cytoplasm, where they are synthesized, across membranes. This essential cellular process typically engages membrane-embedded channels like the ubiquitous and essential Sec translocase. Secreted proteins and the translocase assemble in large complexes and demonstrate remarkable, multi-level dynamics. These are unapproachable with crystallography and NMR. Instead, this proposal will ...
Sabbatical Hideaki Mizuno: Serial femtosecond crystallography to reveal structural dynamics of proteins KU Leuven
The aim of the sabbatical is to master the cutting-edge technology of time resolved X-ray crystallography (TR-SFX) with X-ray free electron laser (XFEL). XFEL is the next generation X-ray technology that generates extremely short (10 fs), strong, and coherent pulses. Thanks to these properties, XFEL is a breakthrough in structural biology, especially exploring structural dynamics of proteins in fs to ps time resolution. TR-SFX requires ...
Reputation and Structural Reforms of Public Organizations: Explaining Temporal Dynamics. University of Antwerp
Efficient solution of fluid-structure interaction problems in structural dynamics Ghent University
In this project computational methods will be developed that can be used for fluid-structure interaction computations for rather slender and lightweight structures under wind loading conditions. This computational technique will allow for studies of ovalling of silos, flutter of bridges, excitation of flexible pipes by vortex shedding, galopping of cables, U+2026
Structural dynamics of secretory protein sorting, targeting, translocation (DynamicSTarT) KU Leuven
component is the Sec translocase, a nanomachine that recognizes exported proteins and takes them out of cell membranes. Pathogenic bacteria use the Sec system to export proteins such as toxins. To control pathogenicity and exploit it for biopharmaceuticals production we need to understand how it works. Scientists have identified Sec components and we have previously determined essential novel signals that allow exported proteins to find it. ...
Bcl-2/IP3R channel structural dynamics underlying complex formation, function and disease (BInamics) KU Leuven
Anti-apoptotic Bcl-2 proteins not only act the mitochondria where they prevent the release of pro-cell death factors but also function at the endoplasmic reticulum (ER), the organelle that serves as the main calcium-storage site in mammalian cells. At the ER, Bcl-2, via its “BH4 domain”, directly inhibits the IP3 receptor, a large calcium-release channel, preventing mitochondrial Ca2+ overload and thus cell death to occur. Previous studies ...
Structural dynamics of the oil market Ghent University
We study time variation in oil market dynamics.
Structural Equation Modeling and the Social Relations Model: challenges arising from a longitudinal study assessing dynamics in stepfamilies Ghent University
Stepfamily members affect each other’s thoughts and feelings and gradually establish as such stepfamily relationships. Using a design in which all members report on their relationships with all other members at three occasions, the Social Relations Model allows to study whether individual, relation-specific or family effects steer the development of stepfamily relationships and how these sources evolve over time.
Aristotle’s view of language as a dynamic system: the interplay between structural and pragmatic functions KU Leuven
This project aims to demonstrate that through the synergetic interaction between the various structural levels and through the contribution of the context of language use to linguistic meaning language for Aristotle is a dynamic system. In shifting the focus from sign-internal properties (which have been the central object of discussion for centuries) to language as a dynamic system in Aristotle’s linguistic thought, the present study will ...