Syntenin, a novel target to counteract cancer progression KU Leuven
Multiple studies indicate that the gain-of-function of syntenin-1 (hereupon referred to as ‘syntenin’) acts as a positive regulator of invasion and metastasis, in various tumors. Consistently, syntenin affects several signaling pathways that are of known relevance for the cancer process. For example, syntenin enhances the fibronectin-induced assembly of integrin-β1 signaling complexes with FAK and c-Src, resulting in the activation of FAK and ...