Projects
Pituitary deficiency and aging: stem cell role and regenerative potential KU Leuven
Stem cell therapy for the treatment of gastrointestinal motility disorders: targeting defects in neuronal wiring KU Leuven
Defining key regulators of neural stem cell self-renewal and differentiation. University of Antwerp
Study of the molecular mechanisms by which chronic intestinal inflammation affects stem cell function leading to epithelial inflammation and cancer development Ghent University
Chronic inflammation contributes to tumor promotion and progression, and many of the tumor-promoting effects of inflammation depend on the activation of the transcription factor NF-κB. Interference with NF-κB signalling therefore represents a potential new therapeutic approach. Our project concerns the study of how NF-kB-dependent inflammation affects intestinal tissue physiology and can contribute to the development of intestinal cancer....
The Study of the Myocardial Regenerative Capacities of Cardiac Atrial Appendage Stem Cells. Hasselt University
Adaptive hydrogels combined with mesenchymal stem cells to treat bone cysts in horses Ghent University
The presence of an osseous cyst-like lesion (OCLL) severely affects the sports career of a horse and its economic value. Thus far, therapeutic approaches fail to meet the expected demands in terms of functional recovery and/or absence of radiographic evidence of OCLL after treatment. In this project, we aim to restore full functionality of horses suffering from lameness due to the presence of OCLL and eliminate any radiographic abnormality ...
Generation of oocytes from isolated stem cells in pigs. University of Antwerp
Bridging the gap between the physiological and therapeutic roles of mesenchymal stem cells Ghent University
To unlock the therapeutic potential of mesenchymal stem cells (MSCs), we will focus in this research proposal on the cross-talk between equine MSCs and tenocytes using in vitro cultures mimicking tendon lesions in the horse, as this setting allows us to study the three main regenerative mechanisms of MSCs: secretion of paracrine factors, cell differentiation and immune modulation.
Unraveling the Regenerative Potential of (Equine) Mesenchymal Stem Cells in a Representative in vitro Tendon Injury Model. Ghent University
Equine tendon- and endothelial cells are combined with crosslinkable 3D-printable gelatin hydrogels to establish a representative tendinopathy model after mechanical stimulation. A first screening will be performed to identify metabolites and their pathways involved in tendon (patho-)physiology. Subsequently, the regenerative role of mesenchymal stem cell (MSC) versus fibroblast secretome on these metabolites and their pathways will be ...