Projects
Screening for inhibitors of protein phosphatases that induce mitotic cell death in cancer cells KU Leuven
To this day, cancer is a prevalent disease that accounts for a significant portion of the mortality that is seen in the modern world. The taxanes and vinca alkaloids play a prominent role in the treatment of many types of cancer. These molecules kill cancer cells in mitosis by chronicly activating the spindle assembly checkpoint (SAC) and subsequently inducing mitotic cell death (MCD). However, the clinical use of these molecules has two ...
Exploration of the therapeutic potential of protein phosphatases involved in chromatin signaling. KU Leuven
Genome-wide promotor binding profiling of Protein phosphatase 1 and its major nuclear targeting subunits KU Leuven
The role of the Protein Phosphatase 2A Activator PTPA in KRAS-mutant non-small-cell lung cancer development and treatment resistance KU Leuven
Reversible protein phosphorylation, catalyzed by kinases and phosphatases, is arguably one of the most prominent signaling mechanisms in the human cell. Protein Phosphatase 2A (PP2A) is a major family of Serine/Threonine protein phosphatases of which the members are involved in a broad array of cellular processes, such as mitogenic signaling, growth, cell division, DNA transcription, protein translation, DNA damage signaling and repair, ...
Targeting radiotherapy resistance in Head and Neck Cancers: the potential biomarker role of TIPRL1 and CIP2A, two cellular inhibitors of Protein Phosphatase 2A KU Leuven
Being one of the main post-translational modifications, reversible protein phosphorylation is of major importance in signal transduction regulation. Over the years, the kinases phosphorylating many substrates have been extensively studied, while the protein phosphatases have been lagging behind. The PP2A-like phosphatases PP2A, PP4 and PP6, all have been shown to play a role in the regulation of tumorigenesis and the DNA damage response ...
Regulation of the protein phosphatase scaffold RepoMan during the cell cycle KU Leuven
Protein kinases and phosphatases are antagonistically acting enzymes that cooperate to control the speed, amplitude and specificity of phosphorylation signals in numerous cellular processes, including mitosis. Early mitotic events are characterized by bulk phosphorylation of specific proteins by kinases such as CDK1/Cyclin B and Aurora B. The mitotic exit depends on protein phosphatases, mainly PP1 and PP2A, which remove phosphate groups from ...