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Exploration of the therapeutic potential of protein phosphatases involved in chromatin signaling.

Our research group has a long-standing expertise in protein phosphatase 1 (PP1) and chromatin signaling and we want to develop chromatin-associated PP1 as a successful therapeutic target. Specific research objectives of this project are: 1. To delineate the role of PP1 in the dynamics of histone phosphorylation. 2. To identify the protein that target PP1 to histones. 3. To explore how PP1 cross-talks with other histone-modifying enzymes. 4. To select PP1 holoenzymes with a high therapeutic potential. 5. To determine the 3D-structues of selected PP1 holoenzymes. 6. To screen for small-molecule effectors of selected PP1 holoenzymes.
Date:1 Oct 2009  →  30 Sep 2014
Keywords:Histone-modifying enzymes, Therapeutic potential of PP1, Epigenetics, Protein phosphatase 1, Protein (de)phosphorylation, Chromatin signaling
Disciplines:Catalysis and reacting systems engineering, Chemical product design and formulation, General chemical and biochemical engineering, Process engineering, Separation and membrane technologies, Transport phenomena, Other (bio)chemical engineering