The structure of the C-terminal domain of the largest editosome interaction protein and its role in promoting RNA binding by RNA editing ligase L2 Vrije Universiteit Brussel
Trypanosomatids, such as the sleeping sickness parasite Trypanosoma brucei, contain a ?20S RNA-editing complex, also called the editosome, which is required for U-insertion/deletion editing of mitochondrial mRNAs. The editosome contains a core of 12 proteins including the large interaction protein A1, the small interaction protein A6, and the editing RNA ligase L2. Using biochemical and structural data, we identified distinct domains of T. ...