Projects
Drug delivery systems and in vivo efficacy of the serine protease inhibitor UAMC-00050 in a preclinical model for irritable bowel syndrome. University of Antwerp
A fragment-based approach to protease inhibitor development. University of Antwerp
Analyses of serine proteases and serine protease inhibitors : Evolutionary and structural insights KU Leuven
Biopharmaceutical and pharmacokinetic factors determining the biological availibility of oral administrered HIV protease inhibitors. KU Leuven
Active Center-Asisted Selection and Assembly (ACASA): a bottom-up approach to druglike protease inhibitors using caspase 4 as a model target. University of Antwerp
Spatiotemporal control of protease activity by photoactivatable inhibitors KU Leuven
Proteases are involved in the regulation of many biological
processeses in the body. Dysregulation of protease activity plays a
role in many diseases, including cancer, Alzheimer’s disease and
hypertension. Therefore, proteases are considered as interesting
drug targets. It is clear that we need both fundamental understanding
of protease function and efforts to develop protease targeting drugs.
Some protease ...
Preclinical development and evaluation of transporter-based pharmacokinetic boosting of HIV protease inhibitors. KU Leuven
Development of photo-activatable protease inhibitors and activity-based probes and their application in the study of dynamic proteolytic processes KU Leuven
Proteases are involved in many highly regulated biological processes, such as apoptosis, cell-cell communication and blood coagulation. Inhibitors and activity-based probes (ABPs) have been successfully utilized as chemical tools to study these enzymes. However, when studying fast and dynamic processes, local and temporal acivation of these reagents is desirable. Such reagents can first of all be used for basic study of these processes, but ...